Synovial sarcoma of the extremities: prognostic factors for 20 nonmetastatic cases and a new histologic grading system with prognostic significance
DOI:
https://doi.org/10.1590/S1807-59322006000500003Keywords:
Synovial, sarcoma, Extremities, Retrospective studies, Prognosis, Soft tissue neoplasmsAbstract
PURPOSE: To evaluate 20 cases of nonmetastatic synovial sarcoma of the extremities regarding prognostic factors, and to propose a histologic grading system with prognostic significance. METHODS: The cases of 20 patients (14 females and 6 males) with nonmetastatic synovial sarcomas of the extremities treated between 1985 and 1998, were retrospectively evaluated regarding prognostic factors. A histologic grading system with prognostic significance is proposed. RESULTS: The mean follow-up period was 48.4 months (range, 16-116 months). There was local recurrence in 3 cases (15%), microscopic surgical margin being the only prognostic factor identified. Seven patients (35%) died of the disease in a mean postoperative period of 31.7 months (range, 16-53 months), all with pulmonary or brain metastasis. The survival rate was 65% in 48.4 months of follow-up. CONCLUSION: The unfavorable prognostic factors identified regarding survival were high histologic grade, tumors proximal to the knee or elbow, and spontaneous tumor necrosis over 25%. Local recurrence did not have influence on survival in this study. The presence of mast cells appears to have a positive influence on survival, although statistical significance was not reached (P = 0.07). The oncologic and functional result was good in 6 cases (30%), regular in 7 (35%), and poor in 7 cases (35%).Downloads
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Published
2006-10-01
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Section
Clinical Sciences
How to Cite
Baptista, A. M., Camargo, O. P. de, Croci, A. T., Oliveira, C. R. G. de, Azevedo Neto, R. S. de, Giannotti, M. A., Caiero, M. T., Santos, T. M. dos, & Abadi, M. D. (2006). Synovial sarcoma of the extremities: prognostic factors for 20 nonmetastatic cases and a new histologic grading system with prognostic significance . Clinics, 61(5), 381-386. https://doi.org/10.1590/S1807-59322006000500003