Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis

Authors

  • Ricardo Tedeschi Matos Universidade de São Paulo; Faculdade de Medicina; Department of Gastroenterology
  • Rodrigo Schuler Honório Universidade de São Paulo; Faculdade de Medicina; Laboratory of Medical Investigation in Hepatic Pathology
  • Elia Garcia Caldini Universidade de São Paulo; Faculdade de Medicina; Department of Pathology; Laboratory of Cell Biology
  • Claudio Lyoiti Hashimoto Universidade de São Paulo; Faculdade de Medicina; Department of Gastroenterology
  • Marcelo Alves Ferreira Universidade de São Paulo; Faculdade de Medicina; Department of Pathology; Laboratory of Cell Biology
  • Tomás Navarro-Rodriguez Universidade de São Paulo; Faculdade de Medicina; Department of Gastroenterology

DOI:

https://doi.org/10.1590/S1807-59322009000700011

Keywords:

Gastroesophageal Reflux, Dilated, Intercellular Space, Epithelium, Esophagus

Abstract

The purpose of this study was to compare esophageal infusion with 0.1 N hydrochloridric acid (HCl) to esophageal infusion with saline in patients presenting with typical gastroesophageal reflux symptoms and erosive esophagitis. METHODS: Upper gastrointestinal endoscopy was performed on 44 prospective subjects, 29 of whom were included in the study. Eighteen patients presented with normal esophagi (Control Group "C"), nine of whom were infused with HCl and nine with saline. Eleven patients presented with erosive esophagitis (Lesion Group "L"), five of whom were infused with HCl and six with saline. Biopsies of the esophageal mucosa were collected before and after infusions. RESULTS: No statistically significant difference was found between the two types of infusions in terms of the dilation of the intercellular space of the esophageal epithelium, regardless of the status of the patient. CONCLUSIONS: Response to HCl infusion cannot be used as a marker for gastroesophageal reflux disease.

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Published

2009-01-01

Issue

Vol. 64 No. 7 (2009)

Section

Clinical Sciences

How to Cite

Matos, R. T., Honório, R. S., Caldini, E. G., Hashimoto, C. L., Ferreira, M. A., & Navarro-Rodriguez, T. (2009). Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis . Clinics, 64(7), 669-674. https://doi.org/10.1590/S1807-59322009000700011