The role of fecal calprotectin in investigating inflammatory bowel diseases

Authors

  • Mustafa Erbayrak Fatih University Hospital; Gastroenterology Department
  • Cansel Turkay Fatih University Hospital; Gastroenterology Department
  • Elife Eraslan Fatih University Hospital; Gastroenterology Department
  • Hulya Cetinkaya Ankara University Hospital; Gastroenterology Department
  • Benan Kasapoglu Fatih University Hospital; Internal Medicine Department
  • Mehmet Bektas Ankara University Hospital; Gastroenterology Department

DOI:

https://doi.org/10.1590/S1807-59322009000500009

Keywords:

Inflammatory bowel diseases, Irritable bowel syndrome, Fecal calprotectin

Abstract

INTRODUCTION: Invasive and non-invasive tests can be used to evaluate the activity of inflammatory bowel diseases. OBJECTIVE: The aim of the present study was to investigate the role of fecal calprotectin in evaluating inflammatory bowel disease activity and the correlation of fecal calprotectin with the erythrocyte sedimentation rate and C reactive protein values in inflammatory bowel disease. METHOD: Sixty-five patients affected with inflammatory bowel disease were enrolled. Twenty outpatients diagnosed with inflammatory bowel disease comprised the control group. RESULTS: In the present study, all patients in the control group had an fecal calprotectin value lower than the cut-off point (50 mg/kg). CONCLUSION: In conclusion, fecal calprotectin was found to be strongly associated with colorectal inflammation indicating organic disease. Fecal calprotectin is a simple and non-invasive method for assessing excretion of macrophages into the gut lumen. Fecal calprotectin values can be used to evaluate the response to treatment, to screen asymptomatic patients, and to predict inflammatory bowel disease relapses.

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Published

2009-05-01

Issue

Section

Clinical Sciences

How to Cite

The role of fecal calprotectin in investigating inflammatory bowel diseases . (2009). Clinics, 64(5), 421-425. https://doi.org/10.1590/S1807-59322009000500009