Surgical resection of lung metastases: results from 529 patients

Authors

  • Riad N. Younes Universidade de São Paulo; Faculdade de Medicina
  • Jefferson L. Gross Hospital do Cancer AC Camargo; Department of Thoracic Surgery
  • Andrea M. Taira Hospital do Cancer AC Camargo; Department of Thoracic Surgery
  • Andrea Aparecida C. Martins Hospital do Cancer AC Camargo; Department of Thoracic Surgery
  • Giuliana Sigolo Neves Hospital do Cancer AC Camargo; Department of Thoracic Surgery

DOI:

https://doi.org/10.1590/S1807-59322009000600008

Keywords:

Lung, Metastases, Resection, Metastasectomy, Prognostic factors

Abstract

OBJECTIVE: The aim of this study is to determine clinical, pathological, and treatment-relevant variables associated with long-term (90-month) overall survival in patients with lung metastases undergoing pulmonary metastasectomy. METHODS: A retrospective review was performed of patients who were admitted with lung metastases, and who underwent thoracotomy for resection, after treatment of a primary tumor. Data were collected regarding demographics, tumor features, treatment, and outcome. RESULTS: Patients (n = 529) were submitted to a total of 776 thoracotomies. Median follow-up time across all patients was 21.6 months (range: 0-192 months). The postoperative complication rate was 9.3%, and the 30-day mortality rate was 0.2%. The ninety-month overall survival rate for all patients was 30.4%. Multivariate analysis identified the number of pulmonary nodules detected on preoperative CT-scan, the number of malignant nodules resected, and complete resection as the independent prognostic factors for overall survival. CONCLUSION: These results confirm that lung metastasectomy is a safe and potentially curative procedure for patients with treated primary tumors. A select group of patients can achieve long-term survival after resection.

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Published

2009-06-01

Issue

Section

Clinical Sciences

How to Cite

Younes, R. N., Gross, J. L., Taira, A. M., Martins, A. A. C., & Neves, G. S. (2009). Surgical resection of lung metastases: results from 529 patients . Clinics, 64(6), 535-541. https://doi.org/10.1590/S1807-59322009000600008