Anti-hypertensive drugs have different effects on ventricular hypertrophy regression

Authors

  • Celso Ferreira Filho Faculdade de Medicina do ABC; Disciplina de Cardiologia; Departamento de Clínica Médica
  • Luiz Carlos de Abreu Faculdade de Medicina do ABC; Departamento de Morfologia e Fisiologia
  • Vitor E. Valenti Faculdade de Medicina do ABC; Departamento de Morfologia e Fisiologia
  • Marcelo Ferreira Faculdade de Medicina do ABC; Disciplina de Cardiologia; Departamento de Clínica Médica
  • Adriano Meneghini Faculdade de Medicina do ABC; Disciplina de Cardiologia; Departamento de Clínica Médica
  • José Alexandre Silveira Faculdade de Medicina do ABC; Disciplina de Cardiologia; Departamento de Clínica Médica
  • Andrés R. Pérez Riera Faculdade de Medicina do ABC; Disciplina de Cardiologia; Departamento de Clínica Médica
  • Eduardo Colombari Faculdade de Medicina do ABC; Departamento de Morfologia e Fisiologia
  • Neif Murad Faculdade de Medicina do ABC; Disciplina de Cardiologia; Departamento de Clínica Médica
  • Paulo Roberto Santos-Silva Faculdade de Medicina do ABC; Disciplina de Cardiologia; Departamento de Clínica Médica
  • Lovian José Henrique Pereira da Silva Faculdade de Medicina do ABC; Disciplina de Cardiologia; Departamento de Clínica Médica
  • Luiz Carlos Marques Vanderlei Universidade Estadual Paulista; Faculdade de Ciências e Tecnologia; Departamento de Fisioterapia
  • Tatiana D. Carvalho Universidade Federal de São Paulo; Disciplina de Cardiologia; Departamento de Medicina
  • Celso Ferreira Universidade Federal de São Paulo; Disciplina de Cardiologia; Departamento de Medicina

DOI:

https://doi.org/10.1590/S1807-59322010000700012

Keywords:

Hypertrophy, Cardiomyopathy, Hypertrophic, Left ventricle hypertension, Cardiology

Abstract

OBJECTIVES: There is a direct relationship between the regression of left ventricular hypertrophy (LVH) and a decreased risk of mortality. This investigation aimed to describe the effects of anti-hypertensive drugs on cardiac hypertrophy through a meta-analysis of the literature. METHODS: The Medline (via PubMed), Lilacs and Scielo databases were searched using the subject keywords cardiac hypertrophy, antihypertensive and mortality. We aimed to analyze the effect of anti-hypertensive drugs on ventricle hypertrophy. RESULTS: The main drugs we described were enalapril, verapamil, nifedipine, indapamina, losartan, angiotensin-converting enzyme inhibitors and atenolol. These drugs are usually used in follow up programs, however, the studies we investigated used different protocols. Enalapril (angiotensin-converting enzyme inhibitor) and verapamil (Ca++ channel blocker) caused hypertrophy to regress in LVH rats. The effects of enalapril and nifedipine (Ca++ channel blocker) were similar. Indapamina (diuretic) had a stronger effect than enalapril, and losartan (angiotensin II receptor type 1 (AT1) receptor antagonist) produced better results than atenolol (selective β1 receptor antagonist) with respect to LVH regression. CONCLUSION: The anti-hypertensive drugs induced various degrees of hypertrophic regression.

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Published

2010-01-01

Issue

Vol. 65 No. 7 (2010)

Section

Review

How to Cite

Ferreira Filho, C., Abreu, L. C. de, Valenti, V. E., Ferreira, M., Meneghini, A., Silveira, J. A., Riera, A. R. P., Colombari, E., Murad, N., Santos-Silva, P. R., Silva, L. J. H. P. da, Vanderlei, L. C. M., Carvalho, T. D., & Ferreira, C. (2010). Anti-hypertensive drugs have different effects on ventricular hypertrophy regression . Clinics, 65(7), 723-728. https://doi.org/10.1590/S1807-59322010000700012