Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients

Authors

  • Fazile Hatipoglu Erdem Sifa Hospital; Department of Physical Medicine and Rehabilitation
  • Saliha Karatay Ataturk University; Medical Faculty; Department of Physical Medicine and Rehabilitation
  • Kadir Yildirim Ataturk University; Medical Faculty; Department of Physical Medicine and Rehabilitation
  • Ahmet Kiziltunc Ataturk University; Medical Faculty; Department of Biochemistry

DOI:

https://doi.org/10.1590/S1807-59322010000200009

Keywords:

Ankylosing Spondylitis, Paraoxonase, Arylesterase, Antioxidant enzymes, Oxidative stress

Abstract

OBJECTIVES: The aim of this study was to investigate the activities of serum paraoxonase and arylesterase in patients with ankylosing spondylitis with respect to those of healthy controls, to assess whether these enzyme levels are related to disease activity and functional capacity. METHODS: The study included 32 patients with ankylosing spondylitis whose diagnoses were made according to the modified New York criteria as well as 25 healthy controls matched for age and sex. The Bath Ankylosing Spondylitis Disease Activity Index and the Bath Ankylosing Spondylitis Functional Index were applied to the ankylosing spondylitis patients. As laboratory parameters, the erythrocyte sedimentation rate and serum C-reactive protein level were measured in patients and control subjects. Paraoxonase and arylesterase enzyme activities were measured using appropriate methods. RESULTS: No statistically significant differences (p>;0.05) were found between the ankylosing spondylitis patients and controls in terms of serum paraoxonase or arylesterase levels. Furthermore, there was no correlation between clinical and laboratory parameters in patients with ankylosing spondylitis. CONCLUSION: Serum paraoxonase and arylesterase levels in ankylosing spondylitis patients may not differ from those of healthy controls, and there is no significant correlation between antioxidant parameters and the Bath Ankylosing Spondylitis Disease Activity Index or Bath Ankylosing Spondylitis Functional Index scores in ankylosing spondylitis patients. Further research is needed to provide deeper understanding of this disease.

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Published

2010-01-01

Issue

Section

Clinical Sciences

How to Cite

Erdem, F. H., Karatay, S., Yildirim, K., & Kiziltunc, A. (2010). Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients . Clinics, 65(2), 175-179. https://doi.org/10.1590/S1807-59322010000200009