Actinic lesions in fishermen's lower lip: clinical, cytopathological and histopathologic analysis

Authors

  • Karine Piñera-Marques Universidade do Sul de Santa Catarina; General Pathology Department
  • Silvia Vanessa Lorenço University of São Paulo Dental School; General Pathology Department
  • Luiz Fernando Ferraz da Silva Universidade de São Paulo; Faculdade de Medicina; Department of Pathology
  • Mirian Nacagami Sotto Universidade de São Paulo; Faculdade de Medicina; Department of Pathology
  • Paulo Campos Carneiro Universidade de São Paulo; Faculdade de Medicina; Department of Pathology

DOI:

https://doi.org/10.1590/S1807-59322010000400003

Keywords:

Actinic cheilitis, Lip carcinoma, Pre-malignant lesion, Exfoliative cytology

Abstract

INTRODUCTION: Actinic cheilitis (AC) is considered to be a pre-malignant lesion or an incipient and superficial form of lip squamous cell carcinoma. It is commonly found in individuals whose occupational activities are related to chronic sun exposure and the definitive diagnosis is performed with biopsy. Althoug Exfoliative cytology has been used as a screening procedure to evaluate cancer of the oral cavity no studies have proposed the use of exfoliative cytologic analysis to evaluate and diagnose AC. OBJECTIVE: The purpose of this study was to evaluate lower lip lesions on fishermen related to chronic solar exposure using clinical, cytologic and histopathologic analyses. PATIENTS AND METHODS: Smears taken from the vermilion of the lower lips of 125 fishermen and 30 control individuals were subjected to cytologic analysis. RESULTS: The harvested cells were sufficient for cytologic analysis in 83.2% of the samples. Sixteen fishermen exhibited prominent lower lip lesions that justified biopsy and histological studies. In total, 4 specimens were malignant (3.2%), and 12 displayed epithelial dysplasia, demonstrating that the prevalence of epithelial dysplasia and malignant lesions was high among the fishermen population. These conditions were strongly associated with infiltration and blurring of the vermilion margin of the lower lip. CONCLUSION: The cytologic analysis was not useful for detecting epithelial dysplasia or malignant alterations.

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Published

2010-01-01

Issue

Section

Clinical Sciences

How to Cite

Piñera-Marques, K., Lorenço, S. V., Silva, L. F. F. da, Sotto, M. N., & Carneiro, P. C. (2010). Actinic lesions in fishermen’s lower lip: clinical, cytopathological and histopathologic analysis . Clinics, 65(4), 363-367. https://doi.org/10.1590/S1807-59322010000400003