Frequency of the mdr-1 C>;T gene polymorphism in patients with COPD
DOI:
https://doi.org/10.1590/S1807-59322010001100010Keywords:
COPD, MDR-1 gene, T allele frequency, Transporter glycoprotein, Reverse-hybridizationAbstract
BACKGROUND AND AIM: The multi-drug resistant-1 (MDR-1) gene is located on human chromosome 7 and encodes a glycosylated membrane protein that is a member of the ATP-binding cassette transporters superfamily. The aim of the study was to reveal the role of the C3435T MDR-1 gene polymorphism in chronic obstructive pulmonary disease. METHOD: DNA samples from 41 patients with chronic obstructive pulmonary disease and 50 healthy control participants were used to compare MDR-1 gene profiles. Genotyping assays were performed using the StripAssay technique that is based on reverse-hybridization. RESULTS: The T allele polymorphism in the MDR-1 gene located at position 3435 in exon 26 was shown to correlate with chronic obstructive pulmonary disease. CONCLUSION: These preliminary results suggest that the T allele polymorphism of the MDR-1 gene is associated with chronic obstructive pulmonary disease.Downloads
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Published
2010-01-01
Issue
Section
Clinical Sciences
How to Cite
Dogan, Ömer T., Katrancioglu, N., Karahan, O., Sanli, G. C., Zorlu, A., & Manduz, Şinasi. (2010). Frequency of the mdr-1 C>;T gene polymorphism in patients with COPD . Clinics, 65(11), 1115-1117. https://doi.org/10.1590/S1807-59322010001100010