Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients
DOI:
https://doi.org/10.1590/S1807-59322011001000006Keywords:
Febrile neutropenia, Inflammatory markers, Procalcitonin, Sensitivity, SpecificityAbstract
OBJECTIVE: This study aimed to examine the association between different inflammatory markers and specific clinical endpoints in patients with febrile neutropenia. METHOD: We prospectively evaluated the expression of procalcitonin (PCT), interleukin 8 (IL-8), induced protein-10, tumor necrosis factor alpha (TNF-a), two soluble TNF-a receptors (sTNF-R I and sTNF-R II), monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1 alpha, and eotaxin in 37 episodes of febrile neutropenia occurring in 31 hospitalized adult onco-hematologic patients. Peripheral blood samples were collected in the morning at inclusion (day of fever onset) and on days 1, 3, and 7 after the onset of fever. Approximately 2-3 ml of plasma was obtained from each blood sample and stored at -80°C. RESULTS: The sTNF-R II level at inclusion (day 1), the PCT level on the day of fever onset, and the change (day 3 - day 1) in the IL-8 and eotaxin levels were significantly higher in patients who died during the 28-day follow-up. A requirement for early adjustment of antimicrobial treatment was associated with higher day 3 levels of IL-8, sTNF-R II, PCT, and MCP-1. CONCLUSION: Procalcitonin, sTNF-R II, IL-8, MCP-1, and eotaxin could potentially be used to assess the risk of death and the requirement for early adjustment of antimicrobial treatment in febrile, neutropenic onco-hematologic patients. The levels of the other markers showed no association with any of the evaluated endpoints.Downloads
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Published
2011-01-01
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Section
Clinical Sciences
How to Cite
Neuenschwander, L. C., Bittencourt, H., Ribeiro, A. F. T., Teixeira, A. L., Teixeira, M. M., Teixeira, J. C., & Nobre, V. (2011). Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients . Clinics, 66(10), 1699-1705. https://doi.org/10.1590/S1807-59322011001000006