Associations of obesity defined comprehensively by body mass index and body fat percentage with osteopenia

Abstract

Objective: To explore the association of obesity comprehensively defined by Body Mass Index (BMI) and Body Fat percentage (BF%) with osteopenia. Methods: In this cross-sectional study, data of adult men and postmenopausal women aged ≥ 50 years old were obtained from the National Health and Nutrition Examination Surveys (NHANES) database. Weighted logistic regression analysis was conducted to investigate the association of BF% obesity with osteopenia in participants who had different gender and BMI obesity conditions. The association of obesity comprehensively evaluated by BMI and BF% with osteopenia was also explored in the total population and in gender subgroups. Results: Among 1720 eligible subjects, 1054 had osteopenia. Multivariate analysis suggested that in males, BMI obesity combined with BF% obesity was associated with higher osteopenia odds compared to BMI obesity only (Odds Ratio [OR = 4.01], 95% Confidence Interval [95% CI 1.43‒11.27]). Compared to participants with both BMI and BF% obesity, those with BMI obesity have lower osteopenia odds (OR = 0.46, 95% CI 0.28‒0.76), whereas those with BF% obesity have higher odds of osteopenia (OR = 2.03, 95% CI 1.35‒3.05, p = 0.002). In females, compared to BMI obesity combined with BF% obesity, BF% obesity (OR = 3.37, 95% CI 1.47‒7.73) or non-obesity (OR = 2.11, 95% CI 1.18‒3.75) was respectively associated with higher osteopenia odds. In males, BMI obesity was linked to lower osteopenia odds compared to both BMI and BF% obesity (OR = 0.25, 95% CI 0.10‒0.62). Conclusions: The comprehensively assessed obesity by BMI and BF% may be more meaningful in the evaluation of potential osteopenia risk, as well as further prevention and intervention of osteoporosis.