Relationship between plasminogen activator inhibitor type-1 (PAI-1) gene polymorphisms and osteoporosis in Turkish women

Authors

  • Merih Ozgen Eskisehir Osmangazi University; Faculty of Medicine; Department of Physical Medicine and Rehabilitation
  • Didem Turgut Cosan Eskisehir Osmangazi University; Faculty of Medicine; Department of Medical Biology
  • Fulya Doganer Eskisehir Osmangazi University; Faculty of Medicine; Department of Medical Biology
  • Ahu Soyocak Eskisehir Osmangazi University; Faculty of Medicine; Department of Medical Biology
  • Onur Armagan Eskisehir Osmangazi University; Faculty of Medicine; Department of Physical Medicine and Rehabilitation
  • Hasan Veysi Gunes Eskisehir Osmangazi University; Faculty of Medicine; Department of Medical Biology
  • Irfan Degirmenci Eskisehir Osmangazi University; Faculty of Medicine; Department of Medical Biology
  • Gulsah Ogutler Ozkara Eskisehir Osmangazi University; Faculty of Medicine; Department of Physical Medicine and Rehabilitation
  • Fezan Sahin Mutlu Eskisehir Osmangazi University; Faculty of Medicine; Department of Biostatistics and Medical Informatics

DOI:

https://doi.org/10.6061/clinics/2012(11)13

Keywords:

Osteoporosis, Polymorphism, Plasminogen Activator Inhibitor Type-1 (PAI-1) Gene, Bone Mineral Density, Turkish Women

Abstract

OBJECTIVE: The development of osteoporosis is associated with several risk factors, such as genetic structures that affect bone turnover and bone mass. The impact of genetic structures on osteoporosis is not known. Plasminogen activator inhibitor type-1 regulates the bone matrix and bone balance. This study assessed the correlation between plasminogen activator inhibitor type-1 gene 4G/5G polymorphisms and osteoporosis in a population of Turkish women. METHODS: A total of 195 postmenopausal female patients who were diagnosed with osteoporosis (Group I) based on bone mineral density measurements via dual-energy x-ray absorptiometry and 90 females with no osteoporosis (Group II) were included in this study. Correlations between PAI-1 gene 4G/5G polymorphisms and osteoporosis were investigated through the identification of PAI-1 gene 4G/5G polymorphism genotypes using the polymerase chain reaction. RESULTS: No significant differences in the genotype and allele frequency of 4G/5G plasminogen activator inhibitor type-1 polymorphisms were observed between the two groups, and both groups exhibited the most frequently observed 4G5G genotype. CONCLUSION: No correlation between the development of osteoporosis in the female Turkish population and 4G/5G plasminogen activator inhibitor type-1 gene polymorphisms was observed.

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Published

2012-11-01

Issue

Section

Clinical Sciences

How to Cite

Ozgen, M., Cosan, D. T., Doganer, F., Soyocak, A., Armagan, O., Gunes, H. V., Degirmenci, I., Ozkara, G. O., & Mutlu, F. S. (2012). Relationship between plasminogen activator inhibitor type-1 (PAI-1) gene polymorphisms and osteoporosis in Turkish women. Clinics, 67(11), 1299-1302. https://doi.org/10.6061/clinics/2012(11)13