The concept of archetype in immunology
DOI:
https://doi.org/10.11606/issn.2178-6224v19i2p197-215Keywords:
Archetype, Granuloma, Immune archetype, Immune system, Philosophy of immunologyAbstract
introduction of the archetype concept in Immunology was proposed in 2019. Considering the broad and complex functions of the immune system, the collection of different cell types and cytokines, gene expression programs and cellular plasticity, the archetype concept in this area could play an organizing role for the generation of new immunological practices and theories. In this paper I analyze the concept of immune archetype, and I briefly explore the origin of the term and its meanings in some non-biological contexts and in significant biological contexts, such as morphoanatomy, neurobiology and ecology. In light of these considerations, I propose a new immune archetype, the granuloma, a complex and evolutionarily conserved cellular structure. I conclude this work by reviewing the meanings of archetype in the different contexts, comparing them with that proposed to immunological phenomena, and contributing toan understating of topics of interest to the philosophy of immunology.
References
ARAÚJO, Alexandra Paiva; ARRAIS-SILVA Wagner Welber; GIORGIO, Selma. Infection by Leishmania amazonensis in mice: A potential model for chronic hypoxia. Acta Histochemica, 114(8): 797-804, 2012. DOI: https://doi.org/10.1016/j.acthis.2012.01.007
ARAÚJO, Alexandra Paiva; FREZZA, Tarsila Ferraz; ALLEGRETTI, Silmara Marques; GIORGIO, Selma. Hypoxia, hypoxia-inducible factor-1α and vascular endothelial growth factor in a murine model of Schistosoma mansoni infection. Experimental Molecular Pathology, 89: 327-333, 2010. DOI: https://doi.org/10.1016/j.yexmp.2010.09.003
COMBES, Alexis; SAMAD, Bushra; KRUMMEL, Matthew. Defining and using immune archetypes to classify and treat cancer. Nature Reviews Cancer, 23: 491-505, 2023. DOI: https://doi.org/10.1038/s41568-023-00578-2
CRONAN, Mark; BEEMAN, Rebecca; ROSENBERG, Allison; SAELENS, Joseph; JOHNSON, Matthew; OEHLERS, Stefan; SISK, Dana;, SMITH Kristen; MEDVITZ, Neil; MILLER, Sara; TRINH, Le; FRASER, Scott; MADDEN, John; TURNER, Joanne; STOUT, Jason; LEE, Sunhee; TOBIN, David. Macrophage epithelial reprogramming underlies mycobacterial granuloma formation and promotes infection. Immunity, 45: 861-876, 2016. DOI: https://doi.org/10.1016/j.immuni.2016.09.014
DARWIN, Charles. On the Origin of Species. New York: MacMillan & Co. Ltd., [1859] 1962.
DELVES, Peter; MARTIN, Seamus; BURTON, Dennis; ROITT, Ivan Maurice. Essential immunology. 13th edition. Chichester: John Wiley & Sons, Inc., 2017.
GIORGIO, Selma. Macrófagos. Pp. 689-704, in: CARVALHO, Hernandes Faustino; COLLARES-BUZATO Carla Beatriz (Org.). Células: uma abordagem multidisciplinar. Barueri, SP: Editora Manole, 2005.
GIORGIO, Selma. Macrophages: plastic solutions to environmental. Inflammation Research, 2: 835-843, 2013. DOI: https://doi.org/10.1007/s00011-013-0647-7
GIORGIO, Selma; GALLO-FRANCISCO, Pedro Henrique; ROQUE, Guilherme Augusto Sanches; SILVA, Marina Floró. Granulomas in parasitic diseases: the good and the bad. Parasitology Research, 119: 3165-3180, 2020. DOI: https://doi.org/10.1007/s00436-020-06841-x
HARRISON, Oliver; LINEHAN, Jonathan; SHIH Han-Yu; BOULADOUX, Nicolas; HAN, Seong-Ju; SMELKINSON, Margery; SEN, Shurjo; BYRD, Allyson; ENAMORADO, Michel; YAO, Chen; TAMOUTOUNOUR, Samira; VAN LAETHEM, Fracois; HURABIELLE, Charlotte; COLLINS, Nicholas; PAUN, Andrea; SALCEDO, Rosalba; O´SHEA, John; BELKAID, Yasmine. Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury. Science, 363(6422): eaat6280, 2019. DOI: https://doi.org/10.1126/science.aat6280
HELMING, Laura; GORDON, Siamon. The molecular basis of macrophage fusion. Immunobiology 212: 785-793, 2008. DOI: https://doi.org/10.1016/j.imbio.2007.09.012
IM, Kwok; COMBES Alexis; SPITZER, Matthew; SATPATHY, Ansuman; KRUMMEL, Matthew. Archetypes of checkpoint-responsive immunity. Trends in Immunology, 42: 960-972, 2021. DOI: https://doi.org/10.1016/j.it.2021.09.007
JUNG, Gustav. Os arquétipos e o inconsciente coletivo. Trad. M. L. Appy; D. M. R. Ferreira da Silva. Petrópolis, Rio de Janeiro: Vozes, 2000. (Obras Completas de Carl Gustav Jung, vol. IX/1.
LENZI, Henrique Leonel; ROMANHA, Waldomiro; SANTOS, Rita MariaZorzenon dos; ROSAS, Alicia; MOTA, Ester Maria; MANSO, Pedro Paulo de Abreu; CAPUTO, Luzia; PELAJO-MACHADO, Marcelo. Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure. Memórias do Instituto Oswaldo Cruz, 101(1): 219-231, 2006. DOI: https://doi.org/10.1590/S0074-02762006000900034
MAJOR, João Carlos. Archetypes and code biology. BioSytems, 208: 104501, 2021. DOI: https://doi.org/10.1016/j.biosystems.2021.104501.
MORAES, Alessandra Regina Dhorm Pimentel; TAVARES, Guilherme Diniz; ROCHA, Francisca Janaina Soares,DE PAULA, Eneida; GIORGIO, Selma. Effects of nanoemulsions prepared with essential oils of copaiba- and andiroba against Leishmania infantum and Leishmania amazonensis infections. Experimental Parasitology, 187: 12-21, 2018. DOI: https://doi.org/10.1016/j.exppara.2018.03.005
MUJAL, Adriana; KRUMMEL Matthew. Immunity as a continuum of archetypes. Science 364(6435): 28-29, 2019. DOI: https://doi.org/10.1126/science.aau8694.
MURRAY, Peter. Macrophage polarization. Annual Review of Physiology, 79: 541-566, 2017. DOI: https://doi.org/10.1146/annurev-physiol-022516-034339
NOOR, Elad; MILO, Ron. Efficiency in evolutionary trade-offs. Science, 336: 1114-1115, 2012. DOI: https://doi.org/10.1126/science.1223193
OWEN, Richard. On the archetype and homologies of the vertebrate skeleton. London: Richard and John E. Taylor, 1848.
PAGÁN, Antonio; RAMAKRISHNA, Lalita. The formation and function of granulomas. Annual Review of Immunology, 36: 639-665, 2918. DOI: 10.1146/annurev-immunol-032712-10002
PHILO, On flight and finding. On the change of names. On dreams. Translated by: F. H. Colson, G. H. Whitaker. Cambridge: Harvard University Press, 1934. (Loeb Classical Library, 275).
PLATÃO. Diálogos. Trad. José Américo Motta Pessanha; José Cavalcante de Souza; Jorge Paleikat; João Cruz Costa. São Paulo: Abril Cultural, 1979.
PRADEU, Thomas. Apport de la philosophie à la question de l’immunogénicité. La Presse Médicale, 39(7-8): 747-752, 2010. DOI: https://doi.org/10.1016/j.lpm.2010.03.012
ROCHA, Francisca Janaina Soares; PEREIRA, Caroline Louise Diniz; MELO, Fabio Lopes; SOARES, Cynthia Regina Pedrosa; PAZ, Silvania Tavares; GIORGIO, Selma. Expression on hypoxia-inducible factor-1α in human tegumentary leishmaniosis caused by Leishmania braziliensis. Annals of Parasitology, 64: 73-766, 2018. DOI: https://doi.org/10.17420/ap6401.136
RUPKE, Nicolaas Adrianus. Owen’s vertebrate archetype. Isis, 84: 231-251, 1993. DOI: https://doi.org/10.1086/356461
SHOVAL, Oren; SHEFTEL, Hila; SHINAR, Guy; HART, Yuval; RAMOTE, Omer; MAYO, Avi; DEKEL, Erez; KAVANAGH, Kathryn; ALON, Uri. Evolutionary trade-offs, pareto optimality, and the geometry of phenotype space. Science, 336: 1157-1160, 2012. DOI: https://doi.org/10.1126/science.1217405
SILVERSTEIN, Arthur. A history of immunology. San Diego: Academic Press, 1989.
TAUBER, Alfred. Immunity: The evolution of an idea. New York: Oxford University Press, 2017.
THOGERSEN, Juliane Charlote; MORUP Morten; DAMKIAER Soren; JELSBAK Lars. Archetypal analysis of diverse Pseudomonas aeruginosa transcriptomes reveals adaptation in cystic fibrosis airways. BMC Bioinformatics, 14: 279-294, 2013. DOI: https://doi.org/10.1186/1471-2105-14-279
YOUNG, Bruce Adams. On the necessity of an archetypal concept in morphology: with special reference to the concepts of ‘structure’ and ‘homology’. Biology and Philosophy, 8: 225-248, 1993.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Filosofia e História da Biologia
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The published manuscripts become the property of the journal Philosophy and History of Biology, and the authors accept the terms of this license and agree to assign the copyright for publication, in addition to agreeing with the publication's commitment to offering open access to all of its content. The information and concepts issued in signed papers are the sole responsibility of their authors.
Funding data
-
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Grant numbers 30439/2021-4
cademia.edu
