Respiratory system parameters and clinical markers in children with cystic fibrosis
DOI:
https://doi.org/10.1590/Keywords:
Adolescent, Cystic Fibrosis, Clinical Markers, Child, Pulmonary Function, Respiratory MechanicsAbstract
This study aimed to investigate the relationship
between respiratory system parameters and clinical markers
in individuals with cystic fibrosis (CF), as well as to compare
individuals with altered oscillometric parameters to those
with values within normal range. This cross-sectional
analytical study involved children and adolescents with
CF. Data collected included anthropometric measurements,
disease severity, bacterial colonization, genetic mutations,
and parameters from impulse oscillometry (IOS) and
spirometry. A total of 115 evaluations were conducted.
Correlation was found between respiratory system
parameters and the association of total airway resistance
(R5) and 5 Hz reactance (X5) with genetic mutations, BMI
percentiles, and disease severity. Significant differences
were observed between the TypicalX5 and AlteredX5
groups (FEV1% and FEF25-75%, p<0.001) and the TypicalR5
and AlteredR5 groups (FEV1% and FEF25-75%, p<0.001). Height,
FEV1 (L), and FEF25-75% (L) explained 69.2% of variations in
X5 (kPa), while height and FEV1 (L) together explained
68.2% of variations in R5. Conclusion: This study verified
the relationship between spirometric and oscillometric
parameters, and found that R5 and X5 are linked to
genetic mutation, BMI percentile, and disease severity Routine spirometry, as well as weight and height assessment,
are essential in the management of lung disease
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Copyright (c) 2025 Tayná Castilho, Renata Maba Gonçalves Wamosy, Patricia Morgana Rentz Keil, Bruna Weber Santos, Tatiana Godoy Bobbio, Camila Isabel Santos Schivinsk
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