Dose-response effect of a dentifrice formulation with low fluoride concentration: an in vitro study
DOI:
https://doi.org/10.1590/S1517-74912002000400014Keywords:
Dentifrices, Fluorine, Caries, Fluorosis, dentalAbstract
The utilization of dentifrices with low fluorine concentration, for children under 6 years of age, has been suggested to reduce the risks of dental fluorosis. However, in order to have anticariogenic potential, the dentifrice should form loosely-bound fluorine (CaF2) on dental enamel. Considering that the formation of CaF2 is a function inversely related to pH, dentifrices with pH 5.5, with 275, 550 and 1,100 ppm ;(NaF/silica) were developed in order to assess dose-response effects. A comparison between those dentifrices, a placebo product and the Crest toothpaste (positive control - standard) was carried out. Furthermore, the bioavailability of dentifrices, in terms of formation of total fluorine (TF), CaF2, and fluorapatite (FA) on human dental enamel, was evaluated. An ion-specific electrode was utilized for the determination of the dosage of fluorine. The results revealed that the dentifrice with 550 ppm ;was more effective than both the placebo and the dentifrice with 275 ppm, presenting no difference in relation to the positive control (p >; 0.05). A dose-effect correlation was observed as to the CaF2 formed. In conclusion, the modified formulation with 550 ppm ;can be considered as effective as the standard dentifrice with 1,100 ppm, and its utilization would be safer with regard to dental fluorosis.Downloads
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Published
2002-12-01
Issue
Section
Bioquímica
How to Cite
Dose-response effect of a dentifrice formulation with low fluoride concentration: an in vitro study. (2002). Pesquisa Odontológica Brasileira, 16(4), 361-365. https://doi.org/10.1590/S1517-74912002000400014