Pharmacokinetic evaluation of lamivudine and zidovudine tablets in human plasma

Authors

  • João Eudes do Nascimento Universidade Federal de Pernambuco; Departamento de Ciências Farmacêuticas
  • Nereide Stela Santos Magalhães Laboratório de Imunopatologia Keizo-Asami
  • Roseane Maria Ribeiro Laboratório de Imunopatologia Keizo-Asami
  • Adriana Pontes Laboratório de Imunopatologia Keizo-Asami
  • Antônio José Alves Universidade Federal de Pernambuco; Departamento de Ciências Farmacêuticas

DOI:

https://doi.org/10.1590/S1516-93322004000100010

Keywords:

Pharmacokinetic, Lamivudine, Zidovudine

Abstract

The purpose of this work was an evaluation of the pharmacokinetic profile from lamivudine and zidovudine combination tablets, produced by Laboratório Farmacêutico do Estado de Pernambuco - LAFEPE. The formulation was administered in 10 volunteers and the concentration-time serum profile was observed from both antiretroviral agents during 12 hours. From concentration-time serum profile the pharmacokinetic parameters for both drugs were calculated by statistical methods. The results were compared with those from experiments carried out by other authors referred in this paper. Differences between the results obtained herein and those from other authors were not significant. The kinetic profile for both substances was not modified by the anti-retroviral combination.

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Published

2004-03-01

Issue

Section

Original Papers

How to Cite

Pharmacokinetic evaluation of lamivudine and zidovudine tablets in human plasma. (2004). Revista Brasileira De Ciências Farmacêuticas, 40(1), 59-66. https://doi.org/10.1590/S1516-93322004000100010