Determination of 17beta-estradiol in dosage formulations: gel and patch

Authors

  • Clarice Yakabe Serviço de Assistência Farmacêutica; Hospital do Servidor Público Estadual Francisco Morato de Oliveira
  • Akimi Mori Honda Serviço de Assistência Farmacêutica; Hospital do Servidor Público Estadual Francisco Morato de Oliveira
  • João Fernandes Magalhães Serviço de Assistência Farmacêutica; Hospital do Servidor Público Estadual Francisco Morato de Oliveira

DOI:

https://doi.org/10.1590/S1516-93322005000300009

Keywords:

17beta-estradiol, Visible spectrophotometry, Gel. Patch. Azo-compound

Abstract

A visible spectrophotometry method was developed for quantification of 17beta-estradiol in gel and in patch, tranformations by using diazotised sulfanilamide as the colorimetric reagent. The azo-compound formed showed a maximum absorption in 480 nm, and the reaction was linear in a concentration range from 10,0 to 28,0 µg/mL. When applied to dosage formulations it showed to be precise and accurate.

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Published

2005-09-01

Issue

Vol. 41 No. 3 (2005)

Section

Original Papers

How to Cite

Determination of 17beta-estradiol in dosage formulations: gel and patch. (2005). Revista Brasileira De Ciências Farmacêuticas, 41(3), 359-364. https://doi.org/10.1590/S1516-93322005000300009