Antimicrobial activity of Senecio heterotrichius DC.

Authors

  • Leandro Nicolodi Francescato Universidade Federal de Santa Maria; Centro de Ciências da Saúde; Departamento de Farmácia Industrial
  • Regis Augusto Norbert Deuschle Universidade Federal de Santa Maria; Centro de Ciências da Saúde; Departamento de Farmácia Industrial
  • Carlos Augusto Mallmann Universidade Federal de Santa Maria; Departamento de Medicina Veterinária Preventiva
  • Sydney Hartz Alves Universidade Federal de Santa Maria; Departamento de Microbiologia
  • Berta Maria Heinzmann Universidade Federal de Santa Maria; Centro de Ciências da Saúde; Departamento de Farmácia Industrial

DOI:

https://doi.org/10.1590/S1516-93322007000200010

Keywords:

Senecio heterotrichius DC^i2^santimicrobial activ, Germacrene D, Asteraceae

Abstract

This work describes the evaluation of the antimicrobial activity of CH2Cl2 and EtOH extracts obtained by the maceration of the aerial parts of Senecio heterotrichius DC. against bacterial and fungal pathogens by broth microdilution method. The CH2Cl2 extract showed the best activity against Candida krusei (MIC 0.25 mg/mL) and a moderate activity against Staphyllococcus aureus (MIC 2.5 mg/mL). The EtOH extract was inactive against the tested microorganisms. Besides, one of the main constituents of CH2Cl2 extract was isolated, and its spectroscopic analysis indicated the presence of a sesquiterpene identified as germacrene D.

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Published

2007-06-01

Issue

Vol. 43 No. 2 (2007)

Section

Original Papers

How to Cite

Antimicrobial activity of Senecio heterotrichius DC. (2007). Revista Brasileira De Ciências Farmacêuticas, 43(2), 239-245. https://doi.org/10.1590/S1516-93322007000200010