Ortogenesis, stress and psychoactive substances addiction

Authors

  • Cleopatra da Silva Planeta Universidade Estadual Paulista; Faculdade de Ciências Farmacêuticas; Departamento de Princípios Ativos Naturais e Toxicologia; Laboratório de Neuropsicofarmacologia
  • Fábio Cardoso Cruz Universidade Estadual Paulista; Faculdade de Ciências Farmacêuticas; Departamento de Princípios Ativos Naturais e Toxicologia; Laboratório de Neuropsicofarmacologia
  • Marcelo Tadeu Marin Universidade Estadual Paulista; Faculdade de Ciências Farmacêuticas; Departamento de Princípios Ativos Naturais e Toxicologia; Laboratório de Neuropsicofarmacologia
  • Moacyr Luiz Aizenstein Universidade de São Paulo; Instituto de Ciências Biomédicas; Laboratório de Psicofarmacologia
  • Roberto DeLucia Universidade de São Paulo; Instituto de Ciências Biomédicas; Laboratório de Psicofarmacologia

DOI:

https://doi.org/10.1590/S1516-93322007000300003

Keywords:

Stress, Addiction, Psychostimulants, Ortogenesis

Abstract

The investigation of the mechanisms of drug abuse and addiction showed great advances in the last decades. New concepts emerged from the scientific evidences on behavioral and neural aspects of this phenomenon. However, the biggest challenge for the future is the identification of which risk factors are implicated in the transition from controlled to compulsive drug use. Stress has been pointed as an important factor related to initiation, maintenance and relapse to drug use. In the present paper we discuss the concepts and theories of drug addiction, and the main behavioral pre-clinical evidences showing the relationship between stress and psychostimulant addiction.

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Published

2007-09-01

Issue

Vol. 43 No. 3 (2007)

Section

Revisão

How to Cite

Ortogenesis, stress and psychoactive substances addiction. (2007). Revista Brasileira De Ciências Farmacêuticas, 43(3), 335-346. https://doi.org/10.1590/S1516-93322007000300003