Effect of Stryphnodendron adstringens (barbatimão) bark on animal models of nociception

Authors

  • Juliana Oliveira de Melo Department of Pharmacy and Pharmacology; Laboratory of Inflammation
  • Tânia Hiromi Endo Department of Pharmacy and Pharmacology; Laboratory of Inflammation
  • Luiz Eduardo Bersani-Amado Department of Pharmacy and Pharmacology; Laboratory of Inflammation
  • Arthur Estivalet Svidzinski Department of Pharmacy and Pharmacology; Laboratory of Inflammation
  • Silmara Baroni Department of Pharmacy and Pharmacology; Laboratory of Inflammation
  • João Carlos Palazzo de Mello University of Maringá; Department of Pharmacy and Pharmacology; Laboratory of Pharmacognosy
  • Ciomar Aparecida Bersani-Amado Department of Pharmacy and Pharmacology; Laboratory of Inflammation

DOI:

https://doi.org/10.1590/S1516-93322007000300015

Keywords:

Stryphnodendron adstringens, Barbatimão, Antinociception

Abstract

The antinociceptive activity of the crude extract and fractions of Stryphnodendron adstringens (Martius) Coville (barbatimão) was evaluated. Three experimental models of pain induction were used: abdominal writhing, formalin, and hot plate. The results demonstrated an antinociceptive effect of barbatimão in the experimental models of writhing induced by acetic acid and pain induced by formalin. However, the extracts did not significantly alter latency time on the hot plate in mice. These results suggest that barbatimão extract has a peripheral antinociceptive effect.

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Published

2007-09-01

Issue

Vol. 43 No. 3 (2007)

Section

Original Papers

How to Cite

Effect of Stryphnodendron adstringens (barbatimão) bark on animal models of nociception. (2007). Revista Brasileira De Ciências Farmacêuticas, 43(3), 465-469. https://doi.org/10.1590/S1516-93322007000300015