Evaluation of in vitro percutaneous enhancement effect of papain and pequi oil on diclofenac sodium permeation through human skin

Authors

  • Patrícia Santos Lopes Sorocaba University; Faculty of Pharmacy
  • Claudinéia Aparecida Sales de Oliveira Pinto University of São Paulo; Faculty of Pharmaceutical Sciences; Department of Pharmacy
  • André Rolim Baby University of São Paulo; Faculty of Pharmaceutical Sciences; Department of Pharmacy
  • Maria Valéria Robles Velasco University of São Paulo; Faculty of Pharmaceutical Sciences; Department of Pharmacy
  • Maria Elena Taqueda University of São Paulo; Polytechnic School
  • Telma Mary Kaneko University of São Paulo; Faculty of Pharmaceutical Sciences; Department of Pharmacy

DOI:

https://doi.org/10.1590/S1516-93322008000200008

Keywords:

Papain^i1^sin vitro evaluat, Pequi oil^i1^sin vitro evaluat, In vitro cutaneous permeation^i1^senhanc, Diclofenac sodium^i1^scutaneous permeat

Abstract

The purpose of this research was to determine the potential of papain and pequi oil as penetration enhancers for diclofenac sodium (DS) across human skin in vitro. The permeation studies were conducted with vertical diffusion cells. The enhancers were associated or not in gels in different concentrations. In vitro studies reveled that papain 0.2% (w/v) presented an elevated enhancer property for diclofenac sodium (J = 0.3369 mg/cm²x h). Pequi oil 10% (w/v) generated a reduced flux value (J = 0.1848 mg/cm²x h) and a combination of both enhancers presented a medium value of J = 0.2187 mg/cm²x h. Papain was found to be better enhancer than pequi oil.

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Published

2008-06-01

Issue

Vol. 44 No. 2 (2008)

Section

Original Papers

How to Cite

Evaluation of in vitro percutaneous enhancement effect of papain and pequi oil on diclofenac sodium permeation through human skin. (2008). Revista Brasileira De Ciências Farmacêuticas, 44(2), 225-231. https://doi.org/10.1590/S1516-93322008000200008