Importance of regulatory cytokine gene polymorphisms in hematopoietic stem cell transplantation
DOI:
https://doi.org/10.1590/S1516-93322008000400021Keywords:
Genetic polymorphisms, Cytokines, Graft-versus-host disease, Hematopoietic stem cell^i2^stransplantatAbstract
HLA genetic matching of donor and recipient is an important requirement for optimizing outcome following hematopoietic stem cell transplantation (HSCT). However, other non-HLA genes are being investigated for their role in graft-versus-host disease incidence and severity and in survival, by modulating the intensity of inflammation and tissue injury. These non-HLA-encoded genes include cytokine genes with polymorphisms within the 5' or 3' regulatory sequences of the genes. The polymorphisms or microsatellites may alter the transcription factor binding sites within the gene promoters and the amount of cytokine produced. This chapter summarizes the potential role of these genetic polymorphisms regarding the cytokines in predicting outcome of HSCT.Downloads
Download data is not yet available.
Downloads
Published
2008-12-01
Issue
Section
Original Papers
How to Cite
Importance of regulatory cytokine gene polymorphisms in hematopoietic stem cell transplantation. (2008). Revista Brasileira De Ciências Farmacêuticas, 44(4), 739-748. https://doi.org/10.1590/S1516-93322008000400021