Characterization of the hypoglycemic drug glibenclamide

Authors

  • Christiane Gino Colu Nery Universidade Federal de Minas Gerais; Departamento de Produtos Farmacêuticos
  • Maria Arlete da Silva Pires Universidade Federal de Minas Gerais; Departamento de Produtos Farmacêuticos
  • Gerson Antônio Pianetti Universidade Federal de Minas Gerais; Departamento de Produtos Farmacêuticos
  • Cristina Duarte Vianna-Soares Universidade Federal de Minas Gerais; Departamento de Produtos Farmacêuticos

DOI:

https://doi.org/10.1590/S1516-93322008000100008

Keywords:

Hypoglycemic agent, Glibenclamide^i2^scharacterizat

Abstract

Glibenclamide (GLIB) or glyburide, a second-generation hypoglycemic agent is orally used in the form of tablets for the treatment of diabetes mellitus. Bulk GLIB has a low aqueous solubility and it may yield low drug release in the dissolution test, causing variabilility in the treatment. This work evaluates the bulk GLIB features, which may influence drug release profile, hence, bioavailability, by means of techniques such as nitrogen sorption analysis, laser diffraction, thermal analysis, IV/UV spectroscopy and X-ray analysis.

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Published

2008-03-01

Issue

Vol. 44 No. 1 (2008)

Section

Original Papers

How to Cite

Characterization of the hypoglycemic drug glibenclamide. (2008). Revista Brasileira De Ciências Farmacêuticas, 44(1), 61-73. https://doi.org/10.1590/S1516-93322008000100008