Predictor of quality of life in individuals with moderate Parkinson's disease
DOI:
https://doi.org/10.11606/issn.1981-4690.v35i1p15-24Keywords:
Fear of falling, Motor signs, Postural instability, Activities of daily livingAbstract
The purpose of this study was to verify among the motor and nonmotor dysfunctions and the fear of falling the main predictors for poor quality of life in individuals in stages 2 and 3 of Parkinson ́s disease (PD). Thirty-nine individuals with PD (64.1±9.1 years, 10.3±4.7 duration of disease) evaluated in “on” state (fully medicated) participated of the study. Motor dysfunctions were assessed using the following tests: Unifi ed Parkinson’s Disease Rating Scale part III motor subscale score (UPDRS-III), timed up and go test, Balance Evaluation System Test (BESTest), one-repetition maximum (1RM) in the leg press. Nomotor dysfunctions were assessed using the following tests: Montreal Cognitive Assessment (MoCA), Beck Depression Inventory (BDI) and Pittsburgh Sleep Quality Index (PSQI). The fear of falling was as-sessed by Falls Effi cacy Scale-International (FES-I). Quality of life was assessed using the Parkinson ́s Disease Questionnaire- 39 (PDQ-39). A multiple regression linear, stepwise method was employed. Only the FES-I score entered into multiple linear regression model and showed a high ability to explain the quality of life score of individual with PD (R2 adjusted = 0.73, p<0.0001). Thus, as clinical implication, it is possible to suggest that physical training strategies that promote a decrease in fear of falling can positively impact on the quality of life of individuals with PD.
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References
Fahn S. Description of Parkinson's disease as a clinical syndrome. Ann N Y Acad Sci. 2003;991:1-14.
Jankovic J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008;79(4):368-76.
Marsden CD. Parkinson's disease. Lancet. 1990;335(8695):948-52.
Muslimovic D, Post B, Speelman JD, Schmand B, de Haan RJ, Group CS. Determinants of disability and quality of life in mild to moderate Parkinson disease. Neurology. 2008;70(23):2241-7.
Barbieri FA, Rinaldi NM, Santos PC, Lirani-Silva E, Vitorio R, Teixeira-Arroyo C, et al. Functional capacity of Brazilian patients with Parkinson's disease (PD): relationship between clinical characteristics and disease severity. Arch Gerontol Geriatr. 2012;54(2):e83-8.
Carod-Artal FJ, Ziomkowski S, Mourao Mesquita H, Martinez-Martin P. Anxiety and depression: main determinants of health-related quality of life in Brazilian patients with Parkinson's disease. Parkinsonism Relat Disord. 2008;14(2):102-8.
Winter Y, von Campenhausen S, Arend M, Longo K, Boetzel K, Eggert K, et al. Health-related quality of life and its determinants in Parkinson's disease: results of an Italian cohort study. Parkinsonism Relat Disord. 2011;17(4):265-9.
Martinez-Martin P, Rodriguez-Blazquez C, Kurtis MM, Chaudhuri KR, Group NV. The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease. Mov Disord. 2011;26(3):399-406.
Adkin AL, Frank JS, Jog MS. Fear of falling and postural control in Parkinson's disease. Mov Disord. 2003;18(5):496-502.
Bloem BR, Grimbergen YA, Cramer M, Willemsen M, Zwinderman AH. Prospective assessment of falls in Parkinson's disease. J Neurol. 2001;248(11):950-8.
Bloem BR, van Vugt JP, Beckley DJ. Postural instability and falls in Parkinson's disease. Adv Neurol. 2001;87:209-23.
Gazibara T, Pekmezovic T, Kisic Tepavcevic D, Svetel M, Tomic A, Stankovic I, et al. Health-related quality of life in patients with Parkinson's disease: Implications for falling. Parkinsonism Relat Disord. 2015;21(6):573-6.
Kadastik-Eerme L, Rosenthal M, Paju T, Muldmaa M, Taba P. Health-related quality of life in Parkinson's disease: a cross-sectional study focusing on non-motor symptoms. Health Quality Life Outcomes. 2015;13:83.
Menon B, Nayar R, Kumar S, Cherkil S, Venkatachalam A, Surendran K, et al. Parkinson's Disease, Depression, and Quality-of-Life. Indian J Psychol Med. 2015;37(2):144-8.
Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology. 1967;17(5):427-42.
Nantel J, McDonald JC, Bronte-Stewart H. Effect of medication and STN-DBS on postural control in subjects with Parkinson's disease. Parkinsonism Relat Disord. 2012;18(3):285-9.
Fasano A, Aquino CC, Krauss JK, Honey CR, Bloem BR. Axial disability and deep brain stimulation in patients with Parkinson disease. Nature Rev Neurol. 2015;11(2):98-110.
Visser JE, Allum JH, Carpenter MG, Esselink RA, Speelman JD, Borm GF, et al. Subthalamic nucleus stimulation and levodopa-resistant postural instability in Parkinson's disease. J Neurol. 2008;255(2):205-10.
Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico--pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992;55(3):181-4.
Goetz CG, Poewe W, Rascol O, Sampaio C, Stebbins GT, Counsell C, et al. Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations. Mov Disord. 2004;19(9):1020-8.
Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189-98.
Corcos DM, Robichaud JA, David FJ, Leurgans SE, Vaillancourt DE, Poon C, et al. A two-year randomized controlled trial of progressive resistance exercise for Parkinson's disease. Mov Disord. 2013;28(9):1230-40.
Silva-Batista C, Corcos DM, Roschel H, Kanegusuku H, Gobbi LT, Piemonte ME, et al. Resistance training with instability for patients with Parkinson's Disease. Med Sci Sports Exerc. 2016;48(9):1678-87.
Dibble LE, Hale TF, Marcus RL, Gerber JP, LaStayo PC. High intensity eccentric resistance training decreases bradykinesia and improves Quality Of Life in persons with Parkinson's disease: a preliminary study. Parkinsonism Relat Disord. 2009;15(10):752-7.
Peto V, Jenkinson C, Fitzpatrick R. PDQ-39: a review of the development, validation and application of a Parkinson's disease quality of life questionnaire and its associated measures. J Neurol. 1998;245(Suppl 1):S10-4.
Fahn S, Elton RL, Members. UP. Unified Parkinson’s disease rating scale. In: Fahn S, Marsden CD, Goldstein M, Calne DB, editors. Recent developments in Parkinson’s disease, Vol 2 Florham Park, NJ: Macmillan Healthcare Information. 1987:153-63, 293-304.
Berg KO, Maki BE, Williams JI, Holliday PJ, Wood-Dauphinee SL. Clinical and laboratory measures of postural balance in an elderly population. Arch Phys Med Rehabil. 1992;73(11):1073-80.
Podsiadlo D, Richardson S. The timed "Up & Go": a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39(2):142-8.
Rinalduzzi S, Trompetto C, Marinelli L, Alibardi A, Missori P, Fattapposta F, et al. Balance dysfunction in Parkinson's disease. BioMed research international. 2015;2015:434683.
Horak FB, Wrisley DM, Frank J. The Balance Evaluation Systems Test (BESTest) to differentiate balance defi cits. Phys Ther. 2009;89(5):484-98.
Brown LE, Weir JP. ASEP procedures recommendation I: accurate assessment of muscular strength and power. J Exercise Physiologyonline. 2001;4(3):1-21.
Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005 Apr;53(4):695-9.
Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consulting Clin Psychol. 1988 Dec;56(6):893-7.
Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Archi Genl Psychiatry. 1961;4:561-71.
Hogl B, Arnulf I, Comella C, Ferreira J, Iranzo A, Tilley B, et al. Scales to assess sleep impairment in Parkinson's disease: critique and recommendations. Mov Disord. 2010;25(16):2704-16.
Carpenter JS, Andrykowski MA. Psychometric evaluation of the Pittsburgh Sleep Quality Index. J Psychosomatic Res. 1998;45(1):5-13.
Buysse DJ, Reynolds CF, 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193-213.
Jonasson SB, Nilsson MH, Lexell J. Psychometric properties of four fear of falling rating scales in people with Parkinson's disease. BMC Geriatr. 2014;14:66.
Yardley L, Beyer N, Hauer K, Kempen G, Piot-Ziegler C, Todd C. Development and initial validation of the Falls Effi cacy Scale-International (FES-I). Age Ageing. 2005;34(6):614-9.
Brozova H, Stochl J, Roth J, Ruzicka E. Fear of falling has greater influence than other aspects of gait disorders on quality of life in patients with Parkinson's disease. Neuro Endocrinol Letters. 2009;30(4):453-7.
Grimbergen YA, Schrag A, Mazibrada G, Borm GF, Bloem BR. Impact of falls and fear of falling on health-related quality of life in patients with Parkinson's disease. J Parkinson's Disease. 2013;3(3):409-13.
Mak MK, Pang MY, Mok V. Gait difficulty, postural instability, and muscle weakness are associated with fear of falling in people with Parkinson's disease. Parkinsons Dis. 2012;2012:901721.
Mak MK, Pang MY. Fear of falling is independently associated with recurrent falls in patients with Parkinson's disease: a 1-year prospective study. J Neurol. 2009;256(10):1689-95.
Shulman LM, Gruber-Baldini AL, Anderson KE, Vaughan CG, Reich SG, Fishman PS, et al. The evolution of disability in Parkinson disease. Mov Disord. 2008;23(6):790-6.
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Fundação de Amparo à Pesquisa do Estado de São Paulo
Grant numbers 2011/042423, 2012/03056-4 e 2013/04970-4
