Study of the distribution of sodium diatrizoate labelled w ith 131 I. on blood, liver and spleen of dogs

Abstract

The distribution of sodium diatrizoate labeled with 131 I., on blood, liver and spleen of dogs, was studied in dogs, though determinations, up to 60 minutes after intravenous injection, of the referred substance. In the blood circulation it was observed a progressive decrease of the contrast medium, but the same fact didn’t occur in the liver and spleen, where the administered substance showed constant concentrations, 15 minutes after the injection. Thus renal excretion associated with the partial retention of the contrast medium in the tissues observed in the first 15 minutes, determined different distribution levels, allowing a better radiographic visualization at this time of the liver and spleen as well as the organs of the urinary system.