C cells in the thyroid of pinealectomized rats
DOI:
https://doi.org/10.1590/S0041-87812003000100005Keywords:
Thyroid, C Cells, Pineal Gland, Rat, CalcitoninAbstract
PURPOSE: To study quantitatively C cells in the thyroids of non-isogenic rats to determine the possible effects of pinealectomy on the number of these cells, and consequently on the synthesis and secretion of calcitonin. METHODS: Twenty male rats of an outbred strain (200-300 g) were used in the present study. One group of 10 animals was pinealectomized 50 days prior to sacrifice. Thyroid tissue was stained for calcitonin (Dako Corporation) at a 1:1500 dilution. The number of C cells observed was expressed as number of cells/cm². Data were analyzed statistically by Mann-Whitney test. RESULTS: The number of C cells in pinealectomized and normal animals ranged from 489 to 2084 per cm² and 227 to 1584 per cm², respectively, a difference that was statistically significant (P <0.05). CONCLUSIONS: These results showed consistent differences in the number of C cells after pinealectomy when compared to controls. We believe that pinealectomy increases the number of C cells in the rat thyroid.Downloads
Published
2003-01-01
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Original Articles
How to Cite
Lima, M. A. de, Lima, L. M. B. de, Freitas, L. L. L., Barbosa, P. F. T., Borges, M. de F., Reis, L., & Pereira, G. de A. (2003). C cells in the thyroid of pinealectomized rats . Revista Do Hospital Das Clínicas, 58(1), 21-26. https://doi.org/10.1590/S0041-87812003000100005