Prevalence of anti-p: Falciparum sporozoite antibodies in adults in the amapa region of Brazil

Authors

  • Virgílio Do Rosario Biomedical Research Institute
  • Michael R. Hollingdale Biomedical Research Institute

Keywords:

Anti-sporozoite antibody, inhibiton of sporozoite invasion (ISI) assay, circumsporozoite precipitation (CSP) assay, immunofluorescent antibody (IFA) assay

Abstract

17 of 20 adult sera from the Amapa region of Brazil were active in the inhibition of P. falciparum sporozoite invasion (ISI) assay which has been correlated with protective antibodies. In contrast 11 sera were positive in IFA tests and 6 were positive in CSP tests. These results suggest that the ISI assay will be useful for evaluating naturally acquired protective anti-sporozoite antibodies in endemic areas, particularly during vaccine efficacy studies using sporozoite-based vaccines.

Downloads

Download data is not yet available.

Downloads

Published

1987-02-01

Issue

Vol. 29 No. 1 (1987)

Section

Epidemiology

How to Cite

Rosario, V. D., & Hollingdale, M. R. (1987). Prevalence of anti-p: Falciparum sporozoite antibodies in adults in the amapa region of Brazil . Revista Do Instituto De Medicina Tropical De São Paulo, 29(1), 63-66. https://revistas.usp.br/rimtsp/article/view/28493