Characterization of mononuclear phagocytes in leprosy skin lesions: a monoclonal study

Authors

  • Euzenir Nunes Sarno Instituto Oswaldo Cruz; Setor de Hanseníase
  • Fátima de Barros Fonseca Alvarenga Universidade do Estado do Rio de Janeiro
  • Leila Maria Machado Vieira Universidade do Estado do Rio de Janeiro
  • Paulo R. Cotrim de Souza Hospital de Bonsucesso; Serviço de Dermatologia

Keywords:

Hanseníase, Macrófagos, Anticorpos monoclonais

Abstract

The skin lesions from 16 leprosy patients were studied by immunofluorescence technique using monoclonal antibodies against monocytes (OKM1 and Anti-Mo) and la-like antigen. Acid phosphatase activity was evaluated using naphthol AS-BI phosphate as substrate. The macrophages seem to be a heterogeneous population in concern with the antigens here studied as well as the enzimatic activity. Ia-like antigen was expressed in a great number of cells throughout the clinical spectrum.

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Published

1988-02-01

Issue

Vol. 30 No. 1 (1988)

Section

Immunology

How to Cite

Sarno, E. N., Alvarenga, F. de B. F., Vieira, L. M. M., & Souza, P. R. C. de. (1988). Characterization of mononuclear phagocytes in leprosy skin lesions: a monoclonal study . Revista Do Instituto De Medicina Tropical De São Paulo, 30(1), 45-50. https://revistas.usp.br/rimtsp/article/view/28558