Evaluation of Plasmodium falciparum response to chloroquine, quinine and mefloquine
Keywords:
Terapêutica da malária, Microtestes de sensibilidade ao Plasmodium falciparumAbstract
The present study is concerned with the analysis of Plasmodium falciparum strains from the Brazilian Amazon Region, collected at the Malaria Laboratory - SUCENT. "In vitro" sensitivity tests were performed using chloroquine (46 samples), quinine (42 samples) and mefloquine (51 samples). Results have shown "in vitro" resistance to chloroquine in 100% of the tested samples, to quinine in 2.4% and to mefloquine in 3L4%. Seven patients were treated with quinine and nine with the triple combination (mefloquine plus sulfadoxine plus pyrimethamine). No correlation was shown between the therapeutic response and the "in vitro" tests.Downloads
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Published
1988-06-01
Issue
Section
Original Articles
How to Cite
Di Santi, S., V.L.F, C. N., Boulos, M., Dutra, A., Ramos, A., Santos, M., & Barata, L. (1988). Evaluation of Plasmodium falciparum response to chloroquine, quinine and mefloquine . Revista Do Instituto De Medicina Tropical De São Paulo, 30(3), 147-152. https://revistas.usp.br/rimtsp/article/view/28579