Histological observations on Montenegro's reaction in man

Authors

  • Wilson Mayrink Universidade Federal de Minas Gerais; Instituto de Ciências Biológicas; Departamento de Parasitologia
  • Antonio Pedro M. Schettini SESAU
  • Paul Williams Universidade Federal de Minas Gerais; Instituto de Ciências Biológicas; Departamento de Parasitologia
  • Pedro Raso Universidade Federal de Minas Gerais; Faculdade de Medicina; Departamento de Patologia
  • Paulo Araujo Magalhães Ministério de Saúde; SUCAM
  • Antonio De Oliveira Lima Fundação Ataulfo Paiva
  • Maria Norma Melo Universidade Federal de Minas Gerais; Instituto de Ciências Biológicas; Departamento de Parasitologia
  • Carlos Alberto da Costa Universidade Federal de Minas Gerais; Faculdade de Farmácia
  • Odair Genaro Instituto Nacional de Pesquisas da Amazonia
  • Magno Dias Universidade Federal de Ouro Preto; Departamento de Ciências Biológicas
  • Marilene Suzan Marques Michalick Universidade Federal de Minas Gerais; Instituto de Ciências Biológicas; Departamento de Parasitologia

Keywords:

American Cutaneous leishmaniasis, Montenegro skin test, Histology of skin changes

Abstract

The Montenegro skin test is widely used as a diagnostic method for American cutaneous leishmaniasis (ACL) but little is known about the histological changes that occur in the skin after administration of the antigen. This report is based on histological studies of biopsied material obtained, from inoculation sites, 48 hours after individuals had been given intradermal injections with a standardized Montenegro antigen. The material examined was obtained from four distinctly different test groups: naturally infected patients with parasitologically proved ACL and with positive Montenegro's reaction; individuals without previous history of ACL and not previously tested with Montenegro antigen; participants in anti-ACL vaccine trials who developed positive reactions to Montenegro antigen after vaccination; other participants in vaccine trials who had negative Montenegro responses after vaccination or had served as controls in the trials. The histological pictures of each group are described and discussed. Histologically, the reactions of vaccinated individuals were indistinguishable from those with naturally acquired infections.

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Published

1989-08-01

Issue

Section

Original Articles

How to Cite

Mayrink, W., Schettini, A. P. M., Williams, P., Raso, P., Magalhães, P. A., Lima, A. D. O., Melo, M. N., Costa, C. A. da, Genaro, O., Dias, M., & Michalick, M. S. M. (1989). Histological observations on Montenegro’s reaction in man . Revista Do Instituto De Medicina Tropical De São Paulo, 31(4), 256-261. https://revistas.usp.br/rimtsp/article/view/28672