Pentavalent antimonial nephrotoxicity in the rat

Authors

  • Joel Paulo R. Veiga Universidade de Brasília; Faculdade de Ciências da Saúde; Departamento de Clínica Médica
  • Rashida Khanam Universidade de Brasília; Faculdade de Ciências da Saúde; Departamento de Clínica Médica
  • Tânia T. Rosa Universidade de Brasília; Faculdade de Ciências da Saúde; Departamento de Clínica Médica
  • Luiz F. Junqueira Jr. Universidade de Brasília; Faculdade de Ciências da Saúde; Departamento de Clínica Médica
  • Plínio C. Brant Universidade de Brasília; Faculdade de Ciências da Saúde; Departamento de Clínica Médica
  • Alberto N. Raick Universidade de Brasília; Faculdade de Ciências da Saúde; Departamento de Patologia
  • Horacio Friedman Universidade de Brasília; Faculdade de Ciências da Saúde; Departamento de Patologia
  • Phillip D. Marsden Universidade de Brasília; Faculdade de Ciências da Saúde; Departamento de Clínica Médica

Keywords:

Pentavalent antimonial, Renal function, Urinary concentrating capacity, Acute tubular necrosis, Rat

Abstract

Aspects of the renal function were assessed in rats treated with the pentavalent antimonials Glucantime (Meglumine Antimoniate, Rhodia) or Pentostam (Sodium Stibogluconate, Wellcome). In dose of 30 mg of Sb v (Glucantime or Pentostam) by 100 mg of weight by day for 30 days, renal functional changes were observed consisting of disturbances in urine concentrating capacity. Such disturbances were expressed by significantly low values of urine osmolality as compared to the basal values previous to the drugs. The decrease in urine osmolality was associated to a significant increase in urinary flow and in negative free-water clearance. There was no alteration in osmolar clearance and in fractional excretion of sodium. These observations suggest an interference of the drugs in the action of the antidiuretic hormone. The disturbance in urine concentration was reversible after a seven days period without the drugs administration. No significant histopathological alterations were observed in the kidneys of the rats treated with the drugs. On the other hand, the rats treated with a high dose of Pentostam (200 mg/100 grams of weight/day) showed the functional and the histopathological alterations of the acute tubular necrosis.

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Published

1990-08-01

Issue

Section

Experimental Therapeutic Assays

How to Cite

Veiga, J. P. R., Khanam, R., Rosa, T. T., Junqueira Jr., L. F., Brant, P. C., Raick, A. N., Friedman, H., & Marsden, P. D. (1990). Pentavalent antimonial nephrotoxicity in the rat . Revista Do Instituto De Medicina Tropical De São Paulo, 32(4), 304-309. https://revistas.usp.br/rimtsp/article/view/28750