Schistosoma mansoni: preclinical studies with 9-acridanone-hydrazones in Cebus monkeys experimentally infected

Authors

  • Paulo Marcos Zech Coelho Universidade Federal de Minas Gerais; Instituto de Ciências Biológicas; Departamento de Parasitologia
  • Leógenes Horácio Pereira Universidade Federal de Minas Gerais; Instituto de Ciências Biológicas; Departamento de Parasitologia

Keywords:

Schistosoma mansoni, Chemotherapy, Cebus monkeys, 9-Acridanone-hydrazones, Active drug

Abstract

Derivatives of acridine (9-Acridanone-hydrazones) were tested in Cebus monkeys experimentally infected with Schistosoma mansoni, at the dosages of 50, 25, and 12.5 mg/kg (p.o., single dose). At least, four compounds seemed to be very promising, promoting alterations in the oogram and reducing the worm burden drastically, even at the lowest dose (12.5 mg/kg). No side effects could be detected after drug administration.

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Published

1991-02-01

Issue

Vol. 33 No. 1 (1991)

Section

Technical Assays

How to Cite

Coelho, P. M. Z., & Pereira, L. H. (1991). Schistosoma mansoni: preclinical studies with 9-acridanone-hydrazones in Cebus monkeys experimentally infected . Revista Do Instituto De Medicina Tropical De São Paulo, 33(1), 50-57. https://revistas.usp.br/rimtsp/article/view/28792