Nephrotic syndrome associated with hepatointestinal schistosomiasis

Authors

  • H. Abensur São Paulo University; Faculty of Medicine; Hospital das Clínicas; Nephrology Division
  • I. Nussenzveig São Paulo University; Faculty of Medicine; Hospital das Clínicas; Nephrology Division
  • L.B. Saldanha São Paulo University; Faculty of Medicine; Hospital das Clínicas; Pathology Division
  • M.S.C. Petalozzi São Paulo University; Faculty of Medicine; Hospital das Clínicas; Nephrology Division
  • M.T. Barros São Paulo University; Faculty of Medicine; Allergy and Immunopathology Division
  • M. Marcondes São Paulo University; Faculty of Medicine; Hospital das Clínicas; Nephrology Division
  • R.T. Barros São Paulo University; Faculty of Medicine; Hospital das Clínicas; Nephrology Division

Keywords:

Schistosoma mansoni, Schistosomal associated nephropathy, Nephrotic syndrome, Hepatointestinal schistosomiasis

Abstract

Schistosomal nephropathy has long been related to the hepatosplenic form of schistosomiasis. In the last few years, 24 patients with hepatointestinal schistosomiasis and the nephrotic syndrome were studied. Aiming at evaluating a possible etiologic participation of schistosomiasis in the development of the nephropathy, this group was comparatively studied with a group of 37 patients with idiopathic nephrotic syndrome. Both groups had a different distribution of the histologic lesions. In the group with schistosomiasis there was a statistically significant prevalence of proliferative mesangial glomerulonephritis (33.3%), whereas in the control group there was prevalence of membranous glomerulonephritis (32.4%). On immunofluorescence, IgM was positive in 94.4% of the patients with schistosomiasis versus 55.0% in the control group (p<0.01). In the group with schistosomiasis, 8 patients evidenced mesangial proliferative glomerulonephritis and 5, membra-noproliferative glomerulonephritis. In both histological types immunofluorescence showed IgM and C3 granular deposits in the glomeruli. The data in this study suggests that mesangial proliferative and membranoproliferative glomerulonephritis, with glomerular granular IgM and C3 deposits, represent the renal lesions of the schistosomiasis associated nephropathy.

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Published

1992-08-01

Issue

Section

Original Article

How to Cite

Abensur, H., Nussenzveig, I., Saldanha, L., Petalozzi, M., Barros, M., Marcondes, M., & Barros, R. (1992). Nephrotic syndrome associated with hepatointestinal schistosomiasis . Revista Do Instituto De Medicina Tropical De São Paulo, 34(4), 273-276. https://revistas.usp.br/rimtsp/article/view/28933