Detecção do DNA do vírus da Hepatite B pela reação em cadeia da polimerase em pacientes com Hepatite Crônica B soropositivos para o anticorpo Anti-HBe
Keywords:
HBV, PCR, replication Markers, chronic HepatitisAbstract
Detection of HBV-DNA by PCR was compared with other serological markers (HBsAg, HBeAg and anti-HBe) in a series of49 Chronic Hepatitis B patients, including 12 with a spontaneous clearance of HBsAg. None of these HBsAg negative cases were PCR positive, but 33/37 (89.2%) HBsAg positive cases were PCR positive (p < 0.0001). Among HBsAg positive samples, nine cases were HBeAg positive and anti-HBe negative, all of them PCR positive. Other 3 patients were HBeAg and anti-HBe positive and these cases were also found PCR positive. A third group included 21 patients anti-HBe positive and HBeAg negative: 19 of them were PCR positive and 2 were PCR negative. The last 4 cases were HBeAg and anti-HBe negative, two of them were PCR positive. The detection of anti-HBe viremic cases in the present series suggest that preC variants could occur in our country. In conclusion, the integrated phase o f chronic hepatitis B seems to be less frequent than it was assumed, when only HBeAg or dot blot hybridization techniques were used. The new term "low replication phase" might favorably replace the former "integrated phase".Downloads
Download data is not yet available.
Downloads
Published
1993-12-01
Issue
Section
Virology
How to Cite
Pinho, J., Santos, C., Gonzalez, C., Bassit, L., Barreto, C., Saez-Alquezar, A., França, A., Carrilho, F., Fonseca, L., Chamone, D., & Silva, L. C. da. (1993). Detecção do DNA do vírus da Hepatite B pela reação em cadeia da polimerase em pacientes com Hepatite Crônica B soropositivos para o anticorpo Anti-HBe . Revista Do Instituto De Medicina Tropical De São Paulo, 35(6), 515-520. https://revistas.usp.br/rimtsp/article/view/29098