Laboratory acquired infection by the virus SP H 114202 (Arenavirus: Arenaviridae): clinical and laboratory findings

Authors

  • Pedro Fernando da Costa Vasconcelos Instituto Evandro Chagas; Serviço de Arbovirus
  • Amélia Paes de Andrade Travassos da Rosa Instituto Evandro Chagas; Serviço de Arbovirus
  • Sueli Guerreiro Rodrigues Instituto Evandro Chagas; Serviço de Arbovirus
  • Robert Tesh Yale University; Yale Arbovirus Research Unit
  • Jorge Fernando Soares Travassos da Rosa Instituto Evandro Chagas; Serviço de Arbovirus
  • Elizabeth Salbé Travassos da Rosa Instituto Evandro Chagas; Serviço de Arbovirus

Keywords:

Arenavirus, Síndrome febril, Doença humana, Infecção de laboratório

Abstract

Here in is described the clinical and laboratorial findings of a laboratory-acquired infection caused by the virus SP H 114202 (Arenavirus, family Arenaviridae) a recently discovered agent responsible for a viral hemorrhagic fever. The patient was sick for 13 days. The disease had an abrupt onset characterized by high fever (39ºC.), headache, chills and myalgias for 8 days. In addition, on the 3rd day, the patient developed nauseas and vomiting, and in the 10th, epigastralgia, diarrheia and gengivorrhagia. Leucopenia was seen within the 1 st week of onset, with counts as low as 2,500 white cells per mm³. Counts performed after the 23th day of the onset were within normal limits. With the exception of moderate lymphocitosis, no changes were observed in differential counts. An increase in the liter of antibodies by complement fixation, neutralization and ELISA (IgM) was detected. Suckling mice and baby hamsters were inoculated intracerebrally with 0.02 ml of blood samples collected in the 2nd and 7th days of disease. Attempts to isolate the virus were also made in Vero cells. No virus was isolated. This virus was isolated before in a single occasion in São Paulo State, in 1990, from the blood of a patient with hemorrhagic fever with a fatal outcome. The manipulation of the virus under study, must be done carefully, since the transmission can occur through aerosols.

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Published

1993-12-01

Issue

Section

Virology

How to Cite

Vasconcelos, P. F. da C., Travassos da Rosa, A. P. de A., Rodrigues, S. G., Tesh, R., Travassos da Rosa, J. F. S., & Travassos da Rosa, E. S. (1993). Laboratory acquired infection by the virus SP H 114202 (Arenavirus: Arenaviridae): clinical and laboratory findings . Revista Do Instituto De Medicina Tropical De São Paulo, 35(6), 521-525. https://revistas.usp.br/rimtsp/article/view/29099