"In vivo" leukocyte chemotaxis in experimental mice Schistosoma mansoni infection

Authors

  • Kirte Maria Teixeira FIOCRUZ; Centro de Pesquisas Aggeu Magalhães; Departamento de Parasitologia
  • Amaury Domingues Coutinho FIOCRUZ; Centro de Pesquisas Aggeu Magalhães; Departamento de Parasitologia
  • Silvia Maria Lucena Montenegro FIOCRUZ; Centro de Pesquisas Aggeu Magalhães; Departamento de Inmunologia

Keywords:

Infection Schistosoma mansoni, Leukocyte chemotaxis

Abstract

The "in vivo" chemotaxis was studied in C57B1/10 mice 10, 30, 50 and 60 days after a Schistosoma mansoni infection in comparison to a control group (uninfected mice). Staphylococcal protein A was injected into a connective tissue air pouch of control and experimental mice and the leukocyte chemotaxis was counted. A decrease in polymorphonuclear (PMN) leukocyte response was found in infected mice in comparison to the control group (p<0.05). The 10 day infected mice showed a decreased PMN leukocyte response respecting the control group (p<0.05) and this finding became more evident 30 and 50 days post-infection. Although the PMN leukocyte response of 60 day infected mice increased in comparison to 50 day infected animals, it was still significantly lower the control response. The mononuclear leukocyte response was not significantly different between infected or uninfected mice.

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Published

1994-06-01

Issue

Section

Brief Communication

How to Cite

Teixeira, K. M., Coutinho, A. D., & Montenegro, S. M. L. (1994). "In vivo" leukocyte chemotaxis in experimental mice Schistosoma mansoni infection . Revista Do Instituto De Medicina Tropical De São Paulo, 36(3), 283-285. https://revistas.usp.br/rimtsp/article/view/29166