Histopathology and immunocytochemical study of type 3 and type 4 complement receptors in the liver and spleen of dogs naturally and experimentally infected with Leishmania (Leishmania) chagasi

Authors

  • Wagner Luiz Tafuri UFMG; Department of General and Anatomical Pathology
  • Washington Luiz Tafuri UFMG; Department of General and Anatomical Pathology
  • Alfredo José Afonso Barbosa UFMG; Department of General and Anatomical Pathology
  • Marilene Susan Marques Michalick UFMG; Department of General and Anatomical Pathology
  • Odair Genaro UFMG; Department of General and Anatomical Pathology
  • João Carlos França-Silva UFMG; Department of General and Anatomical Pathology
  • Wilson Mayrink UFMG; Department of General and Anatomical Pathology
  • Evaldo Nascimento UFMG; Department of General and Anatomical Pathology

Keywords:

Dogs, Leishmania chagasi, Histopathology, Immunocytology, Complement receptors

Abstract

The objective of this study was to compare the histopathological changes and expression of CR3 and CR4 in the liver and spleen of dogs naturally and experimentally infected with L. chagasi. The basic histopathological lesions observed mainly in naturally infected dogs were: epithelioid hepatic granulomas, hyperplasia and hypertrophy of Kupffer cells, Malpigui follicles and mononucleated cells of the red pulp of the spleen. Sections from the liver and spleen by immunocytochemistry technique showed the presence of CD11b,c\CD 18 antigens in the control and infected animals and no qualitative or quantitative differences in the liver. Nevertheless, CD18 was always increased in the spleen of naturally and experimentally infected dogs. These results indicate that there is a difference in the activaton of CD 18 in both experimental and natural cases of canine visceral leishmaniasis that should play an important role in the immunological response to Leishmania chagasi infection.

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Published

1996-04-01

Issue

Section

Parasitology

How to Cite

Tafuri, W. L., Tafuri, W. L., Barbosa, A. J. A., Michalick, M. S. M., Genaro, O., França-Silva, J. C., Mayrink, W., & Nascimento, E. (1996). Histopathology and immunocytochemical study of type 3 and type 4 complement receptors in the liver and spleen of dogs naturally and experimentally infected with Leishmania (Leishmania) chagasi . Revista Do Instituto De Medicina Tropical De São Paulo, 38(2), 81-89. https://revistas.usp.br/rimtsp/article/view/29344