Nutritonal evaluation of pemphigus foliaceus patients on long term glucocorticoid therapy
Keywords:
Pemphigus foliac, Glucocorticoid ther, Nutritional staAbstract
Our objective was to compare food intake and nutritional status of Pemphigus Foliaceus patients (PG) on long term glucocorticoid therapy to a Control Group (CG). Fourteen PG female inpatients receiving prednisone (0.33 ± 0.22mg/kg) for at least 12 months and twelve CG subjects were submitted to nutritional evaluation, including anthropometry, urinary creatinine determination and serum biochemical measurements, besides 48-h-based food intake records. Groups were compared by Chi-square, Mann-Whitney and "t" tests. PG patients and CG were paired, respectively, in relation to age (24.7 ± 14.1 vs. 22.0 ± 12.0 years), body mass index (25.8 ± 6.4 vs. 24.0 ± 5.6kg/m2), daily protein intake (132.9 ± 49.8 vs. 95.2 ± 58.9g), and serum albumin (median; range) (3.8; 3.5-4.1 vs. 3.8; 3.6-5.0g/dl). However, PG patients had lower height-creatinine index (64.8 ± 17.6 vs. 90.1 ± 33.4%), and higher daily energy (3080 ± 1099 vs. 2187 ± 702kcal) and carbohydrate (376.8 ± 135.8 vs. 242.0 ± 80.7g) intakes. Despite high food, protein and energy consumption, PG patients on long term glucocorticoid therapy had lower body muscle mass than controls, while showing high body fat stores. These findings are possibly related to combined metabolic effects of long term corticotherapy and inflammatory disease plus corticosteroid-induced increased appetite.Downloads
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Published
2000-02-01
Issue
Section
Pemphigus Foliaceus
How to Cite
CUNHA, D. F. da, CUNHA, S. F. de C. da, MONTEIRO, J. P., FERREIRA, T. P. S., SANTOS, J. A. M. dos, FURTADO, R. A., MARSSARO, R. S., MUNIZ, R. A., & GOMES, R. A. da S. (2000). Nutritonal evaluation of pemphigus foliaceus patients on long term glucocorticoid therapy . Revista Do Instituto De Medicina Tropical De São Paulo, 42(1), 23-26. https://revistas.usp.br/rimtsp/article/view/30403