Congenital cytomegalovirus infection in a neonatal intensive care unit in Brazil evaluated by PCR and association with perinatal aspects

Authors

  • Daniel Vítor V. SANTOS Universidade Federal de Minas Gerais; Faculdade de Medicina; Departamento de Anatomia Patológica e Medicina Legal
  • Maria Margarida R. SOUZA Universidade Federal de Minas Gerais; Faculdade de Medicina; Departamento de Anatomia Patológica e Medicina Legal
  • Sérgio Henrique L. GONÇALVES Universidade Federal de Minas Gerais; Faculdade de Medicina; Departamento de Anatomia Patológica e Medicina Legal
  • Ana Cristina S. COTTA Universidade Federal de Minas Gerais; Faculdade de Medicina; Departamento de Anatomia Patológica e Medicina Legal
  • Lorenza A. O. MELO Universidade Federal de Minas Gerais; Faculdade de Medicina; Departamento de Pediatria
  • Gláucia M. Q. ANDRADE Universidade Federal de Minas Gerais; Faculdade de Medicina; Departamento de Pediatria
  • Geraldo BRASILEIRO-FILHO Universidade Federal de Minas Gerais; Faculdade de Medicina; Departamento de Anatomia Patológica e Medicina Legal

Keywords:

Cytomegalovi, Congenital infect, Neonatal Intensive Care Unit (NI,

Abstract

Cytomegalovirus (CMV) infection is the most common congenital infection, affecting 0.4% to 2.3% newborns. Most of them are asymptomatic at birth, but later 10% develop handicaps, mainly neurological disturbances. Our aim was to determine the prevalence of CMV shed in urine of newborns from a neonatal intensive care unit using the polymerase chain reaction (PCR) and correlate positive cases to some perinatal aspects. Urine samples obtained at first week of life were processed according to a PCR protocol. Perinatal data were collected retrospectively from medical records. Twenty of the 292 cases (6.8%) were CMV-DNA positive. There was no statistical difference between newborns with and without CMV congenital infection concerning birth weight (p=0.11), gestational age (p=0.11), Apgar scores in the first and fifth minutes of life (p=0.99 and 0.16), mother's age (p=0.67) and gestational history. Moreover, CMV congenital infection was neither related to gender (p=0.55) nor to low weight (<2,500g) at birth (p=0.13). This high prevalence of CMV congenital infection (6.8%) could be due to the high sensitivity of PCR technique, the low socioeconomic level of studied population or the severe clinical status of these newborns.

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Published

2000-06-01

Issue

Section

Virology

How to Cite

SANTOS, D. V. V., SOUZA, M. M. R., GONÇALVES, S. H. L., COTTA, A. C. S., MELO, L. A. O., ANDRADE, G. M. Q., & BRASILEIRO-FILHO, G. (2000). Congenital cytomegalovirus infection in a neonatal intensive care unit in Brazil evaluated by PCR and association with perinatal aspects . Revista Do Instituto De Medicina Tropical De São Paulo, 42(3), 129-132. https://revistas.usp.br/rimtsp/article/view/30422