Mucosal leishmaniasis ("espundia") responsive to low dose of N-methyl glucamine (Glucantime ®) in Rio de Janeiro, Brazil

Authors

  • Manoel Paes de OLIVEIRA-NETO Fundação Oswaldo Cruz; Hospital Evandro Chagas
  • Marise MATTOS Fundação Oswaldo Cruz; Hospital Evandro Chagas
  • Claude PIRMEZ Fundação Oswaldo Cruz; Instituto Oswaldo Cruz; Departamento de Bioquímica e Biologia Molecular
  • Octavio FERNANDES Fundação Oswaldo Cruz; Instituto Oswaldo Cruz; Departamento de Medicina Tropical
  • Sylvio Celso GONÇALVES-COSTA Fundação Oswaldo Cruz; Instituto Oswaldo Cruz; Departamento de Protozoologia
  • Celeste de Freitas Silva de SOUZA Fundação Oswaldo Cruz; Instituto Oswaldo Cruz; Departamento de Protozoologia
  • Gabriel GRIMALDI JUNIOR Fundação Oswaldo Cruz; Instituto Oswaldo Cruz; Departamento de Imunologia

Keywords:

Mucosal leishmaniasis, Leishmania (Viannia) braziliensis, Antimony, Therapy

Abstract

Response to treatment with antimonial drugs varies considerably depending on the parasite strain involved, immune status of the patient and clinical form of the disease. Therapeutic regimens with this first line drug have been frequently modified both, in dose and duration of therapy. A regimen of 20 mg/kg/day of pentavalent antimony (Sb5+) during four weeks without an upper limit on the daily dose is currently recommended for mucosal disease ("espundia"). Side-effects with this dose are more marked in elderly patients, more commonly affected by this form of leishmaniasis. According to our experience, leishmaniasis in Rio de Janeiro responds well to antimony and, in cutaneous disease, high cure rates are obtained with 5 mg/kg/day of Sb5+ during 30 to 45-days. In this study a high rate of cure (91.4%) employing this dose was achieved in 36 patients with mild disease in this same geographic region. Side-effects were reduced and no antimony refractoriness was noted with subsequent use of larger dose in patients that failed to respond to initial schedule.

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Published

2000-12-01

Issue

Section

Leishmaniasis

How to Cite

OLIVEIRA-NETO, M. P. de, MATTOS, M., PIRMEZ, C., FERNANDES, O., GONÇALVES-COSTA, S. C., SOUZA, C. de F. S. de, & GRIMALDI JUNIOR, G. (2000). Mucosal leishmaniasis ("espundia") responsive to low dose of N-methyl glucamine (Glucantime ®) in Rio de Janeiro, Brazil . Revista Do Instituto De Medicina Tropical De São Paulo, 42(6), 321-325. https://revistas.usp.br/rimtsp/article/view/30466