Entomophthoramycosis by Conidiobolus coronatus. Report of a case successfully treated with the combination of itraconazole and fluconazole
Keywords:
Entomophthoramycosis, Zygomycosis, Combination triazole treatment, RhinoentomophthoramycosisAbstract
Rhinoentomophthoramycosis caused by Conidiobolus coronatus in a 61-year old woman was unsuccessfully treated during 8 years with all the antifungals available in the Brazilian market, including potassium iodide for 1 month, sulfamethoxazole plus trimethoprim for 2 months, amphotericin B, total dose of 1130 mg, cetoconazole, 400 mg/day for 6 months, fluconazole, 200 mg/day, for at least 2 months and, itraconazole, 400 mg/day for 2 months, followed by 200 mg/day for 4 more months. Complete clinical and mycological cure was achieved using itraconazol 400 mg/day in association with fluconazol 200 mg/day during 24 months. After cure she was submitted to plastic surgery to repair her facial deformation. Today she remains clinically and mycologically cured after 59/60 months (5 years!) without any specific antifungal. We thus suggest the use of the combination of itraconazole and fluconazole as an additional option for the treatment of this mycosis.Downloads
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Published
2001-08-01
Issue
Section
Case Report
How to Cite
VALLE, A. C. F. do, WANKE, B., LAZÉRA, M. dos S., MONTEIRO, P. C. F., & VIEGAS, M. de L. (2001). Entomophthoramycosis by Conidiobolus coronatus. Report of a case successfully treated with the combination of itraconazole and fluconazole . Revista Do Instituto De Medicina Tropical De São Paulo, 43(4), 233-236. https://revistas.usp.br/rimtsp/article/view/30533