In vitro susceptibility to antifungal agents of clinical and environmental Cryptococcus neoformans isolated in Southern of Brazil

Authors

  • Sydney Hartz ALVES Universidade Federal de Santa Maria; Laboratório de Pesquisas Micológicas; Departamento Análises Clínicas e Toxicológicas
  • Loiva T. OLIVEIRA Hospital Universitário de Santa Maria
  • Jane M. COSTA Hospital Universitário de Santa Maria
  • Irina LUBECK Universidade Federal de Santa Maria
  • Agnes Kiesling CASALI Universidade Federal do Rio Grande do Sul; Centro de Biotecnologia; Programa de Pós-graduação em Biologia Celular e Molecular
  • Marilene Henning VAINSTEIN Universidade Federal do Rio Grande do Sul; Centro de Biotecnologia; Programa de Pós-graduação em Biologia Celular e Molecular

Keywords:

Cryptococcus neoformans, Susceptibility, Antifungal agents

Abstract

The purpose of the present study was to compare the susceptibility to four antifungal agents of 69 Cryptococcus neoformans strains isolated from AIDS patients with that of 13 C. neoformans strains isolated from the environment. Based on the NCCLS M27-A methodology the Minimal Inhibitory Concentrations (MICs) obtained for amphotericin B, itraconazole and ketoconazole were very similar for clinical and environmental isolates. Clinical isolates were less susceptible to fluconazole than environmental isolates. The significance of these findings and aspects concerning the importance, role and difficulties of C. neoformans susceptibility testing are also discussed.

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Published

2001-10-01

Issue

Vol. 43 No. 5 (2001)

Section

Mycology

How to Cite

ALVES, S. H., OLIVEIRA, L. T., COSTA, J. M., LUBECK, I., CASALI, A. K., & VAINSTEIN, M. H. (2001). In vitro susceptibility to antifungal agents of clinical and environmental Cryptococcus neoformans isolated in Southern of Brazil . Revista Do Instituto De Medicina Tropical De São Paulo, 43(5), 267-270. https://revistas.usp.br/rimtsp/article/view/30544