Liver histology in co-infection of hepatitis C virus (HCV) and Hepatitis G virus (HGV)

Authors

  • Edna STRAUSS FMUSP; Divisão de Anatomia Patológica
  • Luiz Carlos da Costa GAYOTTO FMUSP; Divisão de Anatomia Patológica
  • Fabian FAY Universidade Nacional de Rosário; Centro de Tecnologia en Salud Publica
  • Oscar FAY Universidade Nacional de Rosário; Centro de Tecnologia en Salud Publica
  • Helena Sabino FERNANDES Fundação Pró-Sangue Hemocentro de São Paulo
  • Dalton de Alencar Fischer CHAMONE Fundação Pró-Sangue Hemocentro de São Paulo

Keywords:

Hepatitis C, Hepatitis G, Liver fibrosis, Inflammatory activity

Abstract

As little is known about liver histology in the co-infection of hepatitis C virus (HCV) and hepatitis G virus (HGV), HGV RNA was investigated in 46 blood donors with hepatitis C, 22 of them with liver biopsy: co-infection HCV / HGV (n = 6) and HCV isolated infection (n = 16). Besides staging and grading of inflammation at portal, peri-portal and lobular areas (Brazilian Consensus), the fibrosis progression index was also calculated. All patients had no symptoms or signs of liver disease and prevalence of HGV / HCV co-infection was 15.2%. Most patients had mild liver disease and fibrosis progression index, calculated only in patients with known duration of infection, was 0.110 for co-infection and 0.130 for isolated HCV infection, characterizing these patients as "slow fibrosers". No statistical differences could be found between the groups, although a lesser degree of inflammation was always present in co-infection. In conclusion co-infection HCV / HGV does not induce a more aggressive liver disease, supporting the hypothesis that HGV is not pathogenic.

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Published

2002-04-01

Issue

Section

Hepatitis

How to Cite

STRAUSS, E., GAYOTTO, L. C. da C., FAY, F., FAY, O., FERNANDES, H. S., & CHAMONE, D. de A. F. (2002). Liver histology in co-infection of hepatitis C virus (HCV) and Hepatitis G virus (HGV) . Revista Do Instituto De Medicina Tropical De São Paulo, 44(2), 67-70. https://revistas.usp.br/rimtsp/article/view/30604