Opportunistic infections in patients with aids admitted to an university hospital of the Southeast of Brazil

Authors

  • Vandack Nobre Federal University of Minas Gerais; Infectious Disease Branch, School of Medicine; Department of Internal Medicine
  • Emanuella Braga Federal University of Minas Gerais; Infectious Disease Branch, School of Medicine; Department of Internal Medicine
  • Abdunnabi Rayes Federal University of Minas Gerais; Infectious Disease Branch, School of Medicine; Department of Internal Medicine
  • José Carlos Serufo Federal University of Minas Gerais; Infectious Disease Branch, School of Medicine; Department of Internal Medicine
  • Pérsio Godoy Federal University of Minas Gerais; School of Medicine; Department of Pathology
  • Nívea Nunes Federal University of Minas Gerais; Infectious Disease Branch, School of Medicine; Department of Internal Medicine
  • Carlos Maurício Antunes Federal University of Minas Gerais; Institute of Biological Sciences; Department of Parasitology
  • José Roberto Lambertucci Federal University of Minas Gerais; Infectious Disease Branch, School of Medicine; Department of Internal Medicine

Keywords:

HIV, AIDS, Opportunistic diseases, Schistosomiasis, Paracoccidioidomycosis

Abstract

Opportunistic diseases in HIV-infected patients have changed since the introduction of highly active anti-retroviral therapy (HAART). This study aims at evaluating the frequency of associated diseases in patients with AIDS admitted to an university hospital of Brazil, before and after HAART. The medical records of 342 HIV-infected patients were reviewed and divided into two groups: group 1 comprised 247 patients before HAART and, group 2, 95 patients after HAART. The male-to-female rate dropped from 5:1 to 2:1for HIV infection. There was an increase in the prevalence of tuberculosis and toxoplasmosis, with a decrease in Kaposi's sarcoma, histoplasmosis and cryptococcosis. A reduction of in-hospital mortality (42.0% vs. 16.9%; p = 0.00002) has also occurred. An agreement between the main clinical diagnoses and autopsy findings was observed in 10 out of 20 cases (50%). Two patients with disseminated schistosomiasis and 2 with paracoccidioidomycosis are reported. Overall, except for cerebral toxoplasmosis, it has been noticed a smaller proportion of opportunistic conditions related to severe immunosuppression in the post HAART group. There was also a significant reduction in the in-hospital mortality, possibly reflecting improvement in the treatment of the HIV infection.

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Published

2003-04-01

Issue

Section

AIDS

How to Cite

Nobre, V., Braga, E., Rayes, A., Serufo, J. C., Godoy, P., Nunes, N., Antunes, C. M., & Lambertucci, J. R. (2003). Opportunistic infections in patients with aids admitted to an university hospital of the Southeast of Brazil . Revista Do Instituto De Medicina Tropical De São Paulo, 45(2), 69-74. https://revistas.usp.br/rimtsp/article/view/30681