ABO System: molecular mimicry of Ascaris lumbricoides

Authors

  • Patricia Ponce de León Universidad Nacional de Rosario; Faculdade de Ciencias Bioquímicas y Farmacéuticas
  • Juana Valverde Universidad Nacional de Rosario; Faculdade de Ciencias Bioquímicas y Farmacéuticas

Keywords:

Ascaris lumbricoides, ABO System, Mimicry

Abstract

A. lumbricoides has been associated to the ABO System by various authors. The objective was to detect ABO System epitopes in A. lumbricoides of groups O, A, B and AB patients. 28 adult parasites were obtained from children to be used as assay material. The patients ABO blood groups were determined. Extracts of A. lumbricoides [AE] were prepared by surgical remotion of the cuticle and refrigerated mechanical rupture. Agglutination Inhibition (AI) and Hemoagglutination Kinetics (HK) tests were used with the [AE]. Of the 28 [AE], eight belonged to O group patients, 15 to A group, three to B group and the remaining two to AB children. The AI Test showed A epitopes in two [AE] of group A patients and B epitopes in two [AE] of group B patients. The HK Test showed B antigenic determiners in two [AE] of group B patients and in two [AE] of group AB patients as well as A antigenic determiners in one [AE] of A group patient. Of the 28 [AE] studied in both tests B epitopes were detected in all [AE] from B and AB patients and A epitopes in three of the 15 [AE] of group A patients. The experiments carried out suggest that A. lumbricoides might absorb A and B antigens from the host, and/or modify the cuticular carbohydrates expression as a kind of antigenic mimicry.

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Published

2003-04-01

Issue

Section

Brief Communication

How to Cite

Ponce de León, P., & Valverde, J. (2003). ABO System: molecular mimicry of Ascaris lumbricoides . Revista Do Instituto De Medicina Tropical De São Paulo, 45(2), 107-108. https://revistas.usp.br/rimtsp/article/view/30689