Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection

Authors

  • Fabio Ribeiro FIOCRUZ; Centro de Pesquisas ‘René Rachou’; Laboratório de Esquistossomose
  • Rômulo Teixeira de Mello Universidade Federal de Minas Gerais; Faculdade de Farmácia; Departamento de Análises Clínicas e Toxicológicas
  • Carlos Alberto Pereira Tavares UFMG; Instituto de Ciências Biológicas; Departamento de Bioquímica e Imunologia
  • John Robert Kusel The University of Glasgow; Division of Biochemistry and Molecular Biology
  • Paulo Marcos Zech Coelho Santa Casa de Misericórdia de Belo Horizonte

Keywords:

Schistosoma mansoni, Praziquantel, Immune Response, Concomitant Immunity

Abstract

The interaction between specific immune response to Schistosoma mansoni and praziquantel (PZQ) was studied in mice. In mice harboring concomitant immunity, 6-day-old parasites treated with PZQ were more effectively removed than 24h treated parasites despite both had a significant worm burden reduction when compared with respective treated controls. These results show that PZQ can be effective at the skin and lung stages of parasite's development mainly acting with a established specific immune response, and particularly at the lung phase.

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Published

2004-08-01

Issue

Vol. 46 No. 4 (2004)

Section

Brief Communication

How to Cite

Ribeiro, F., Mello, R. T. de, Tavares, C. A. P., Kusel, J. R., & Coelho, P. M. Z. (2004). Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection . Revista Do Instituto De Medicina Tropical De São Paulo, 46(4), 231-233. https://revistas.usp.br/rimtsp/article/view/30829