The "in vitro" antifungal activity evaluation of propolis G12 ethanol extract on Cryptococcus neoformans

Authors

  • Fabrício Freitas Fernandes Universidade Federal de Alfenas; Departamento de Ciências Biológicas
  • Amanda Latercia Tranches Dias Universidade Federal de Alfenas; Departamento de Ciências Biológicas
  • Cíntia Lacerda Ramos Universidade Federal de Alfenas; Departamento de Ciências Biológicas
  • Masaharu Ikegaki Universidade Federal de Alfenas; Departamento de Ciências Biológicas
  • Antonio Martins de Siqueira Universidade Federal de Alfenas; Departamento de Ciências Biológicas
  • Marília Caixeta Franco Universidade Federal de Alfenas; Departamento de Ciências Biológicas

Keywords:

Propolis, Antifungal activity, Cryptococcus neoformans

Abstract

Cryptococcosis is a worldwide disease caused by the etiological agent Cryptococcus neoformans. It affects mainly immunocompromised humans. It is relatively rare in animals only affecting those that have received prolonged antibiotic therapy. The propolis is a resin that can present several biological properties, including antibacterial, antifungal and antiviral activities. The standard strain C. neoformans ATTC 90112 was used to the antifungal evaluation. The tests were realized with propolis ethanol extract (PEE) G12 in concentrations from 0.1 to 1.6 mg mL-1. The evaluation of MIC and MFC were done according to DUARTE (2002)5. The inhibitory effect of PEE G12 on the fungal growing was seen at the concentration of 0.2 mg mL-1 and 1.6 mg mL-1 was considered a fungicidal one.

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Published

2007-04-01

Issue

Section

Cryptococcosis

How to Cite

Fernandes, F. F., Dias, A. L. T., Ramos, C. L., Ikegaki, M., Siqueira, A. M. de, & Franco, M. C. (2007). The "in vitro" antifungal activity evaluation of propolis G12 ethanol extract on Cryptococcus neoformans . Revista Do Instituto De Medicina Tropical De São Paulo, 49(2), 93-95. https://revistas.usp.br/rimtsp/article/view/31067