Prevalence of intestinal microsporidiosis in Human Immunodeficiency Virus-infected patients with diarrhea in major United States cities

Authors

  • Mark S. Dworkin National Center for HIV, STD, and TB Prevention
  • Susan E. Buskin Public Health - Seattle and King County
  • Arthur J. Davidson Denver Public Health
  • David L. Cohn Denver Public Health
  • Anne Morse Louisiana Office of Public Health
  • Jeffrey Inungu Louisiana Office of Public Health
  • Michael R. Adams National Center for HIV, STD, and TB Prevention
  • Scott B. McCombs National Center for HIV, STD, and TB Prevention
  • Jeffrey L. Jones National Center for Infectious Diseases; Centers for Disease Control and Prevention
  • Hercules Moura National Center for Infectious Diseases; Centers for Disease Control and Prevention
  • Govinda Visvesvara National Center for Infectious Diseases; Centers for Disease Control and Prevention
  • Norman J. Pieniazek National Center for Infectious Diseases; Centers for Disease Control and Prevention
  • Thomas R. Navin National Center for Infectious Diseases; Centers for Disease Control and Prevention

Keywords:

Intestinal microsporidiosis, Prevalence, HIV-infected patients, Diarrhea

Abstract

To determine the prevalence of intestinal microsporidiosis in HIV-infected patients, we performed a prospective study of HIV-infected patients with diarrheal illnesses in three US hospitals and examined an observational database of HIV-infected patients in 10 US cities. Among 737 specimens from the three hospitals, results were positive for 11 (prevalence 1.5%); seven (64%) acquired HIV through male-to-male sexual contact, two (18%) through male-to-male sexual contact and injection drug use, and one (9%) through heterosexual contact; one (9%) had an undetermined mode of transmission. Median CD4 count within six months of diagnosis of microsporidiosis was 33 cells/µL (range 3 to 319 cells/µL). For the national observational database (n = 24,098), the overall prevalence of microsporidiosis was 0.16%. Prevalence of microsporidiosis among HIV-infected patients with diarrheal disease is low, and microsporidiosis is most often diagnosed in patients with very low CD4+ cell counts. Testing for microsporidia appears to be indicated, especially for patients with very low CD4+ cell counts.

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Published

2007-12-01

Issue

Section

Parasitology

How to Cite

Dworkin, M. S., Buskin, S. E., Davidson, A. J., Cohn, D. L., Morse, A., Inungu, J., Adams, M. R., McCombs, S. B., Jones, J. L., Moura, H., Visvesvara, G., Pieniazek, N. J., & Navin, T. R. (2007). Prevalence of intestinal microsporidiosis in Human Immunodeficiency Virus-infected patients with diarrhea in major United States cities . Revista Do Instituto De Medicina Tropical De São Paulo, 49(6), 339-342. https://revistas.usp.br/rimtsp/article/view/31123