American tegumentary leishmaniasis: langerhans cells in montenegro skin test
Keywords:
Cutaneous leishmaniasis, Delayed type hypersensitivity, Immunopathology, Skin, Langerhans cellsAbstract
This work analyzed the histopathology and epidermal Langerhans cells (LC) of Montenegro skin test (MST) in patients with American tegumentary leishmaniasis (ATL) in order to in situ characterize and compare the immunological reaction of the two major clinical forms of ATL, localized cutaneous leishmaniasis (LCL) and mucocutaneous leishmaniasis (MCL). MST histopathology of both LCL and MCL showed superficial and deep perivascular inflammatory infiltrate composed mainly of lymphocytes and histiocytes. Epidermal LC population was higher in MST biopsies taken from LCL patients when compared to MCL group, at 48 and 72 hours after antigen inoculation. Increased number of epidermal LC displayed in MST biopsies of LCL patients represents specific cellular immunity against parasites. The decrease of LC in MST biopsies of MCL patients does not necessarily indicate a worse specific cellular immunity in this clinical form of leishmaniasis.Downloads
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Published
2008-10-01
Issue
Section
Leishmaniasis
How to Cite
Nogueira, M. F., Sotto, M. N., & Cucé, L. C. (2008). American tegumentary leishmaniasis: langerhans cells in montenegro skin test . Revista Do Instituto De Medicina Tropical De São Paulo, 50(5), 283-286. https://revistas.usp.br/rimtsp/article/view/31203