Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy

Authors

  • José L.F. Vieira Para Federal University; Toxicology Laboratory
  • Andreza L.S. Gomes Para Federal University; Toxicology Laboratory
  • Larissa M.G. Borges Para Federal University; Toxicology Laboratory
  • Erika R. Guimarães Para Federal University; Toxicology Laboratory

Keywords:

Quinine, Quinine levels, Malaria, Chromatography

Abstract

We determined the relationship between plasma and red blood cell concentrations of quinine in children with uncomplicated falciparum malaria from an endemic area of Amazonian region. Quinine was determined by high performance liquid chromatography with ultraviolet detection. In the steady state the ratio between plasma and red blood cell quinine concentration was 1.89 ± 1.25 ranging from 1.05 to 2.34. This result demonstrated that quinine do not concentrate in red blood cell of Brazilian children and characterize the absence of interracial difference in this relationship.

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Published

2009-04-01

Issue

Vol. 51 No. 2 (2009)

Section

Brief Communication

How to Cite

Vieira, J. L., Gomes, A. L., Borges, L. M., & Guimarães, E. R. (2009). Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy . Revista Do Instituto De Medicina Tropical De São Paulo, 51(2), 109-110. https://revistas.usp.br/rimtsp/article/view/31254