Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract

Authors

  • Marley García Parra Instituto de Medicina Tropical Pedro Kourí; Departmento de Parasitología
  • Lianet Monzote Fidalgo Instituto de Medicina Tropical Pedro Kourí; Departmento de Parasitología
  • Judith Mendiola Martinez Instituto de Medicina Tropical Pedro Kourí; Departmento de Parasitología
  • Ana Margarita Montalvo Alvarez Instituto de Medicina Tropical Pedro Kourí; Departmento de Parasitología
  • Olga Valdés Iglesias Instituto de Medicina Tropical Pedro Kourí; Departmento de Parasitología

Keywords:

Leishmania amazonensis, Echinaster (Othilia) echinophorus, Antiprotozoal activity, Saponins

Abstract

In this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC50 values of 62.9 and 37.5 μg.mL-1 respectively. This extract showed a moderate toxicity on macrophages from BALB/c mice. A dose of 100 mg/kg/day was effective when administered during 15 days by intraperitoneal route to BALB/c mice infected experimentally.

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Published

2010-04-01

Issue

Vol. 52 No. 2 (2010)

Section

Leishmaniasis

How to Cite

Parra, M. G., Fidalgo, L. M., Martinez, J. M., Alvarez, A. M. M., & Iglesias, O. V. (2010). Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract . Revista Do Instituto De Medicina Tropical De São Paulo, 52(2), 89-93. https://revistas.usp.br/rimtsp/article/view/31308